We previously reported that type 2 diabetes risk, early impaired glucose tolerance and insulin resistance can be predicted by measuring the fasting levels of certain biomarkers. Here we validated these findings in randomly recruited healthy volunteers (n = 101) based on biomarker expression as well as various non-invasive indices. Weight, body mass index, waist circumference and visceral fat di...

OBJECTIVE: Low-grade systemic inflammation is associated with an increased risk of type 2 diabetes. C-Reactive Protein (CRP), an acute phase protein produced by hepatocytes, may be associated with diabetes. This study aimed to compare serum levels of CRP in women with gestational diabetes mellitus (GDM), impaired glucose tolerance test and control subjects. MATERIALS AND METHODS: In this ca...

Background: Some patients with GDM (Gestational Diabetes Mellitus) still experience impaired glucose tolerance after childbirth and will be affected by diabetes mellitus type 2. Objectives: The aim of this study is to investigate the relationship between hs-CRP serum levels with insulin resistance six weeks after childbirth in patients with gestational diabetes mellitus type 2. Methods: I...

OBJECTIVE The aim of this study was to investigate several macroscopic and microscopic features of placenta in cases with impaired gestational glucose tolerance. METHODS Seventy-five gm World Health Organization criteria for the diagnosis of gestational diabetes and impaired gestational glucose tolerance were followed during the period June 1999 through to June 2000, at the Maternity Hospital...

OBJECTIVE To investigate general practitioners' knowledge of and attitudes to impaired glucose tolerance. DESIGN Mixed methodology qualitative and quantitative study with semistructured interviews, focus groups, and questionnaires. SETTING 34 general practitioners in five primary care groups in the north east of England. RESULTS All the general practitioners had knowledge of impaired gluc...

Sialic acid, oral glucose and plasma lipids were determined in 70 control subjects (age range 20-60) and 150 individuals of (age range 20-60) who were offspring of one type 2 diabetic parent. The number of first degree relatives who had impaired glucose tolerance were 50. The total sialic acid concentration was significantly higher (p<0.05) in the first degree relatives when compared to the con...

OBJECTIVE To determine the sex-specific relationships between glucose intolerance and Shwachman-Kulczycki clinical score, lung function, Brasfield chest-radiograph score, and exercise capacity in patients with cystic fibrosis (CF). METHODS We used a cross-sectional study design and included CF patients ≥ 10 years old. All patients had clinical and nutritional evaluation, oral glucose toleranc...

BACKGROUND To determine the prevalence of diabetes mellitus (DM) and impaired glucose tolerance (IGT) in a rural community (Bengo) of Angola. METHODS A random sample of 421 subjects aged 30 to 69 years (30% men and 70% women) was selected from three villages of Bengo province. This cross-sectional home survey was conducted using a sampling design of stage conglomerates. First, clinical and an...

Glucose tolerance and insulin release were evaluated in 16 families with Friedrich's ataxia. Impaired glucose tolerance differed in incidence according to the method of evaluation, but was increased in number in parents and siblings of Friedreich's cases. Insulin output was not quantitatively different from normal, although the insulin peak was often delayed. This finding, in association with i...