The present study reports on the treatment of bleeding episodes and the natural history of factor VIII inhibitors in 4 patients with acquired haemophilia A postpartum. Low titre type II factor VIII inhibitors in 3 patients and high titre type I inhibitor in 1 patient became apparent immediately to 7 months after delivery. High dose human factor VIII concentrate substitution was effective in con...

conclusions obesity prevalence before and after liver transplantation was comparable. education of obese patients prior to surgery and recommendation of medical nutrition therapy should be appropriate. similar medical care for the non-obese subjects could prevent increase in obesity prevalence. non-corticosteroid immunosuppressive agents had no significant effect on the development of weight ga...

introduction: the long-term use of immunosuppressive agents for prevention of allograft rejection increases the risk of malignancy approximately 100 times as high as that in the general population and kaposi’s sarcoma (ks) is a relatively common malignancy after kidney transplantation. the aim of present study was to investigate the frequency of ks in patients with kidney transplantation in 20 ...

Pyridoxine deficiency leads to impairment of immune responses. It appears that the basic derangement is the decreased rate of production of one-carbon units necessary for the synthesis of nucleic acids. The key factor is a pyridoxine enzyme, serine hydroxymethyltransferase. This enzyme is very low in resting lymphocytes but increases significantly under the influence of antigenic or mitogenic s...

Citation: Chirumbolo S (2015) Alpha-bisabolol, not a matter for cancer therapy. Commentary: " Research on the immunosuppressive activity of ingredients contained in sunscreens ". Alpha-bisabolol, not a matter for cancer therapy. Commentary: " Research on the immunosuppressive activity of ingredients contained in sunscreens " A commentary on Research on the immunosuppressive activity of ingredie...

Reactivated hepatitis B is a potentially serious disorder that can result in liver failure and death. It has been described with a wide variety of immunosuppressive interventions, such as cancer chemotherapy, anti-rejection drugs and the use of tumour necrosis factor-α inhibitors and monoclonal antibody to B-cell antigen. It now appears reasonable to consider transarterial chemoembolization (TA...

VACCINATIONS Patients with IBD are often treated with long-term immunosuppressive therapies and may thus be at increased risk for infections, many of which are preventable with vaccinations (1). All adult patients with IBD, regardless of immunosuppression status, should receive non-live vaccines, including trivalent inactivated influenza vaccine, pneumococcal vaccination (PCV13 and PPSV23), hep...

tricho-dento-osseous syndrome is a rare autosomal dominant disorder. immunosuppressive drugs, though critical to the treatment, have undesirable effects on patient's healing process. this is a case report of a 10-year-old female, suffering from tricho-dento-osseous syndrome who was under treatment with penicillamine. as the dental treatment was sought too late, both central and lateral incisors...

INTRODUCTION  Infectious skin lesions are a common complication in renal transplant patients receiving immunosuppressive therapy. OBJECTIVES  The aim of this study was to assess the prevalence and factors contributing to the development of viral skin infections in kidney transplant patients. PATIENTS AND METHODS  The study included 486 patients, 296 men (60.9%) and 190 women (39.1%), aged 4...

The vast majority of patients with inflammatory bowel disease (IBD) will receive immunosuppressive therapy at some point for their disease, whether for the short term (such as a course of corticosteroids) or long term (such as maintenance therapy with immunomodulators or biologics). The systemic immunosuppression places patients at increased risk for infections. Therefore, it is important that ...