نتایج جستجو برای: immunosuppressive drug
تعداد نتایج: 607565 فیلتر نتایج به سال:
Antimalarial chemotherapy continues to be challenging in view of the emergence of drug resistance, especially artemisinin resistance in Southeast Asia. It is critical that novel antimalarial drugs are identified that inhibit new targets with unexplored mechanisms of action. It has been demonstrated that the immunosuppressive drug rapamycin, which is currently in clinical use to prevent organ-tr...
Whereas the standard immunosuppressive agents foster development of posttransplant lymphoproliferative disorders (PTLDs), the impact of RAD, a macrolide with potent immunosuppressive properties, and other immunosuppressive macrolides on these disorders remains undetermined. We found that RAD had a profound inhibitory effect on in vitro growth of six different PTLD-like Epstein-Barr virus+ lymph...
Immunosuppressive drugs used in the management of heart and lung transplants have a large monetary and quality of life cost due to their side effects. Total lymphoid irradiation (TLI) is one method of minimising the need for or replacing post-operative immunosuppressive drugs. A literature review was conducted on electronic databases using defined search terms. The aim was to establish the indi...
Post renal transplantation, therapeutic drug monitoring of immunosuppressive medications, particularly calcineurin inhibitors, is vital to ensure adequate immunosuppression, prevent nephrotoxicity and neurotoxicity, undue risk opportunistic infections. Tacrolimus has emerged as the preferred CNI over years due its association with reduced rates rejection. An important consideration among patien...
Despite recent improvements in immunosuppressive therapy, hepatic allograft rejection remains a major cause of morbidity and late graft loss in patients undergoing liver transplantation. Although some biochemical tests suggest hepatic allograft damage, the gold standard for defining rejection remains based on morphologic findings. Acute cellular rejection usually occurs within the first 3 weeks...
Individualizing drug therapy by the use of pharmacogenomics offers the opportunity to improve drug efficacy, reduce adverse side effects, and provide cost-effective pharmaceutical care. 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) and azathioprine (AZA) are widely prescribed cytotoxic and immunosuppressive drugs used in the therapy of acute leukaemia, inflammatory bowel diseases, allograft rej...
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