Processed antigen reacts selectively with lymphocytes bearing .appropriate surface immunoglobulin molecules resulting in the clonal proliferation of these cells, produc­ing circulating immunoglobulin (humoral immunity) or non-circulating immunoglobulins (cellular immunity).  High levels of circulating immunoglobulins (lgM & lgG) occur in protozoa and helminths infections. Reaginic antibodies a...

The effect of humoral immunity on the composition of the oral microbiota is less intensively investigated than hygiene and diet, in part due to a lack of simple and robust systems for investigating interactions between salivary immunoglobulins and oral bacteria. Here we report the application of an ex situ method to investigate the specificity of salivary immunoglobulins for salivary bacteria. ...

background:chronic idiopathic thrombocytopenic purpura (itp) is an autoimmune disorder characterized by a low platelet count due to reduced production and higher destruction of the platelets. therapy is aimed at increasing the patient’s platelet count to safe levels and includes a wide variety of treatments, which has a large impact on the patient’s quality of life. health related quality of li...

BACKGROUND Cancer and its treatment are a major cause of secondary immunodeficiency in childhood. Leukaemias are the most frequent pediatric neoplastic diseases and 80 % are lymphoblastic (ALL). The objectives of this study are to describe the epidemiology of children with ALL in our hospital and to analyse the evolution of immunoglobulins' concentration at leukaemia's onset, during its treatme...

BACKGROUND The impact and clinical relevance of pregnancy-related heart failure (HF) on humoral immunity are not known. Heart failure is often characterized by immunoglobulins (Ig) that differ in subclass profile with etiology. Subclass immunoglobulins differ in the biologic information they confer in disease. Therefore, given that progressive gestation is associated with immunologic incompeten...

background: the immunity and health of newborn calf are related to immunoglobulins uptake from colostrum where treatment of colostrum may improve the uptake. objectives: the purpose of this study was to investigate the effect of controlled heat-treating of colostrum and antibiotic addition on immunoglobulins absorption, performance and health parameters of calf. methods: the colostrum pool was ...

Monoclonal gammopathies reflect conditions in which abnormal amounts of immunoglobulins are produced by a clone that developed from a single pro-B germ cell. The condition may reflect a disease process or be benign. The primary purpose of this review is to emphasize routine clinical laboratory techniques that currently are recommended for use in identifying monoclonal gammopathies from serum an...

Placental microvesicles were prepared from ovine placentae and immunoglobulins eluted with 0.5 M glycine buffer pH 2.5. The ability of eluate immunoglobulins to re-associate with isologous (self) and third party acidified microvesicles was tested by ELISA. Ovine placental immunoglobulins re-associated with isologous and third party acidified microvesicles suggesting that at least 2 types of ant...

The presence of immunoglobulins G, A and M was studied in human dental pulps using a quantitative method of radial immunodiffusion. Valid data on the amounts of IgG, IgA and IgM were obtained on the basis of measured concentrations of immunoglobulins in each pulp sample and their correlation with total protein concentrations. The results indicated IgG to be present in 100%, IgA in 15% and IgM i...