نتایج جستجو برای: immunogenic response

تعداد نتایج: 983179  

Journal: :Cancer prevention research 2013
Takashi Kimura John R McKolanis Lynda A Dzubinski Kazi Islam Douglas M Potter Andres M Salazar Robert E Schoen Olivera J Finn

Cancer vaccines based on human tumor-associated antigens (TAA) have been tested in patients with advanced or recurrent cancer, in combination with or following standard therapy. Their immunogenicity and therapeutic efficacy has been difficult to properly evaluate in that setting characterized by multiple highly suppressive effects of the tumor and the standard therapy on the patient's immune sy...

Journal: :The Journal of Experimental Medicine 1971
Hal B. Richerson

Cutaneous basophil hypersensitivity (CBH) was studied for tolerogenic requirements. Graded doses of intravenous ovalbumin (OA) were given to guinea pigs which were subsequently immunized appropriately to produce CBH, classic delayed hypersensitivity (classic DH), and/or antibodies of both passive cutaneous anaphylaxis (PCA) and hemolytic types. Results showed that doses of intravenous antigen s...

2003
Mary L. Disis Lupe G. Salazar

Advances in basic immunology over the past decade have changed the scope and application of cancer vaccines. Perhaps the most important advance is the demonstration that human tumors are immunogenic and the identification of tumor-specific antigens. In fact, dozens of immunogenic proteins have been identified in patients with cancer using high throughput technologies. More importantly, we have ...

2014
Encouse B Golden Derek Frances Ilenia Pellicciotta Sandra Demaria Mary Helen Barcellos-Hoff Silvia C Formenti

Established tumors are typified by an immunosuppresive microenvironment. Countering this naturally occurring phenomenon, emerging evidence suggests that radiation promotes a proimmunogenic milieu within the tumor capable of stimulating host cancer-specific immune responses. Three cryptic immunogenic components of cytotoxic-agent induced cell death-namely, calreticulin cell surface exposure, the...

2016
Nourhan H AbdelAllah Nourtan F Abdeltawab Abeer A Boseila Magdy A Amin

Hepatitis B viral (HBV) infections represent major public health problem and are an occupational hazard for healthcare workers. Current alum-adjuvanted HBV vaccine is the most effective measure to prevent HBV infection. However, the vaccine has some limitations including poor response in some vaccinee and being a frost-sensitive suspension. The goal of our study was to use an alternative natura...

2013
Jael Quintero Diana Carolina Figueroa Rafael Barcelo Linda Breci Humberto Astiazaran-Garcia Lucila Rascon Ramon Robles-Zepeda Adriana Garibay-Escobar Enrique Velazquez-Contreras Gloria Leon Avila Jose Manuel Hernandez-Hernandez Carlos Velazquez

The humoral immune response plays an important role in the clearance of Giardia lamblia. However, our knowledge about the specific antigens of G. lamblia that induce a protective immune response is limited. The purpose of this study was to identify and characterise the immunogenic proteins of G. lamblia in a mouse model. We generated monoclonal antibodies (moAbs) specific to G. lamblia (1B10, 2...

2014
Guido Moll Annika Hult Lena von Bahr Jessica J. Alm Nina Heldring Osama A. Hamad Lillemor Stenbeck-Funke Stella Larsson Yuji Teramura Helene Roelofs Bo Nilsson Willem E. Fibbe Martin L. Olsson Katarina Le Blanc

Investigation into predictors for treatment outcome is essential to improve the clinical efficacy of therapeutic multipotent mesenchymal stromal cells (MSCs). We therefore studied the possible harmful impact of immunogenic ABO blood groups antigens - genetically governed antigenic determinants - at all given steps of MSC-therapy, from cell isolation and preparation for clinical use, to final re...

Journal: :The Journal of Experimental Medicine 1969
J. R. Frey A. L. de Weck H. Geleick W. Lergier

Numerous dinitrophenyl amino acid preparations injected intradermally induced contact hypersensitivity to dinitrochlorobenzene, delayed type skin reactions to DNP-amino acids, and anti-DNP antibodies in guinea pigs. Some DNP-amino adds induced precipitating anti-DNP antibodies in rabbits as well. Some of the DNP-ammo acids studied were regularly immunogenic, possible immunogenic impurities havi...

Journal: :Haematologica 2011
Kamel Ait-Tahar Amanda P Liggins Graham P Collins Andrew Campbell Martin Barnardo Maite Cabes Charles H Lawrie Donald Moir Chris Hatton Alison H Banham Karen Pulford

BACKGROUND Vaccine development targeting the novel immunogenic Per ARNT Sim Domain containing 1 (PASD1) cancer testis antigen represents an attractive therapeutic approach for the significant number of patients with diffuse large B-cell lymphoma who are refractory to conventional treatment. Since CD4-positive T helper cells have crucial roles in promoting and maintaining immune responses to tum...

2004
Terry Lichtor Roberta P Glick InSug O-Sullivan Edward P Cohen

Antigenic differences between normal and malignant cells of the cancer patient form the rationale for clinical immunotherapeutic strategies. Because the antigenic phenotype of neoplastic cells varies widely among different cells within the same malignant cell-population, immunization with a vaccine that stimulates immunity to the broad array of tumor antigens expressed by the cancer cells is li...

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