Policy Forum I t may seem remarkable that, 23 years after the identifi cation of the human immunodefi ciency virus (HIV), there is still denial that the virus is the cause of acquired immune defi ciency syndrome (AIDS). This denial was highlighted on an international level in 2000, when South African president Thabo Mbeki convened a group of panelists to discuss the cause of AIDS, acknowledging...

World Blood Donor Day is celebrated on 14 June every year.1 On that day, countries all around the world express their appreciation for blood donors, whose generous gift of blood have saved the lives of millions of people they have never met. It is a precious gift indeed as the donated red blood cells help to carry suffi cient oxygen to critical tissues during anaemia or blood loss while the der...

Cultured leukemic T-lymphoblasts, incubated in the pres ence of inhibitors of adenosine deaminase, are exquisitely sensitive to growth inhibition by deoxyadenosine. An analogy between this phenomenon and human combined immunodefi ciency disease associated with inborn adenosine deaminase deficiency and the use of inhibitors of adenosine deaminase in the management of T-cell acute lymphoblastic l...

1. Wittkop L, Gunthard HF, de Wolf F, Dunn D, Cozzi-Lepri A, de Luca A, et al. Effect of transmitted drug resistance on virological and immunological response to initial combination antiretroviral therapy for HIV (EuroCoord-CHAIN joint project): a European multicohort study. Lancet Infect Dis. 2011;11:363–71. doi:10.1016/S14733099(11)70032-9 2. Schuurman R, Demeter L, Reichelderfer P, Tijnagel ...

www.thelancet.com Vol 374 October 17, 2009 1329 and women, ”reducing the incidence of genital warts, cervical intraepithelial neoplasia, and cervical cancer by 97%, 91%, and 91%, respectively”. Although the initial expense will be higher, additionally accounting for the prevention of HPV-linked cancers in men (eg, anal, penile, and oropharyngeal cancers) will make this approach cost eff ective....

rituximab or other immunosuppressive treatments should be prescribed cautiously; the possibility for rare complications should be recognized. Because of massive ablation of humoral immunity, the relationship between rituximab and virus infection has been addressed, including varicella–zoster infection, parvovirus B19 infection, and CMV reactivation (7). In immunocompromised patients, rituximab ...

33/2015 Evgeny Kulesskiy Application of Fluorescence Resonance Energy Transfer to Study Syndecan-3 Signaling on the Surface of Neural Cells 34/2015 Juuso Juuri Kainate-Type Glutamate Receptors Modulating Network Activity in Developing Hippocampus 35/2015 Gloria Wissel ABCC2 Transporter and α2 Adrenoceptors: Identifi cation of Novel Compounds and Their Mode of Action 36/2015 Lotta Veistinen Role...

Background: The introduction of human immunodefi ciency virus (HIV) protease inhibitors (PIs) has led to a dramatic decline in the morbidity and mortality associated with HIV infection. However, the concomitant use of PIs and other antiretrovirals (ARVs) can be complicated by drug-drug interactions (DDIs), adversely affecting levels of PIs. Method: A quantitative, retrospective drug utilisation...

1 of 2 DESCRIPTION A previously healthy 31-year-old woman presented to our emergency department with a 1-month history of fever, non-productive cough, malaise and weight loss. She also reported having had low back and left buttock pain for the last 5 months. Stress tests of the sacroiliac joint, namely the lateral pelvic compression test, the fl exion, abduction and external rotation of the hip...

Ten years ago, two articles about malariotherapy in Chinese human immunodefi ciency virus (HIV) patients once again raised ethical issues about this widely used treatment for infectious and mental diseases. Malariotherapy was born in a context where bioethics was not recognized as we do now, and evidence-based medicine was not yet established. During the pre-penicillin era, there was no effi ci...