The applicability to the non-hemolytic streptococci of the technique used for the extraction of a soluble precipitating substance from the hemolytic streptococci is demonstrated. With this substance as antigen, it is demonstrated by means of precipitation and complement fixation that the non-hemolytic streptococci form an antigenically distinct, but entirely heterogeneous group. Such cross-reac...

The study of immune hemolytic anemias has contributed significantly to the understanding of the immune response in the human system in the past. Thus, the concept of receptor specificity – becoming the rationale of the clonal selection theory when trying to explain how the organism avoids autoaggression – has been developed originally upon the study of immune hemolytic anemias, and the question...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a variety of clinical manifestations related to viral tissue damage, as well virally induced immune response. Hyperstimulation the system can serve trigger for autoimmunity. Several immune-mediated have been described in course SARS-CoV-2 infection. Immune thrombocytopenic purpura (ITP) and autoimmune hemo...

Immune-mediated hemolytic anemia is a well-recognized complication of hematopoietic stem cell transplantation. We report on a 6-year-old boy with X-linked adrenoleukodystrophy who developed severe delayed alloimmune hemolytic anemia associated with immune-mediated neutropenia and thrombocytopenia following major ABO incompatible unrelated cord blood transplantation. The patient's cytopenias wer...

in this study, a 2.5-year-old boy suffering from a febrile seizure with normal laboratory tests and a history of immune hemolytic anemia was examined. brain mri demonstrated some tumors in the frontal, parietal, and occipital lobe that corroborated the pathology results of primary central nervous system lymphoma for the patient. the patient was treated with high- dose of methotrexate. our resul...

Anti-D immune globulin (RhIG) is a front-line option in North America for the treatment of immune thrombocytopenia (ITP) in children and adults. Recently, addition of a Food and Drug Administration-mandated black box warning highlighted the risks of intravascular hemolysis, renal failure, and disseminated intravascular coagulation after anti-D infusion, prompting concern within the medical comm...

1. A substance extracted from group A hemolytic streptococcus is described, which induces active immunity in mice, and in rabbits gives rise to precipitins and to protective antibodies passively transferable to mice. 2. The active immunity in mice is principally type-specific, but some degree of non-type-specific immunity is also developed. The passively transferable protective antibodies are t...

objective(s):gemifloxacin is a broad spectrum antibiotic and has shown excellent coverage against a wide variety of microorganisms. in this study, an attempt was made to evaluate the immunomodulatory potential of gemifloxacin in male swiss albino mice in vivo. materials and methods: three doses of gemifloxacin 25 mg/kg, 50 mg/kg and 75 mg/kg were used intraperitoneally (ip) for the evaluation o...

Haematologica/journal of hematology vol. 88(02):February 2003 225 Deist F, Fischer A. Treatment of childhood autoimmune hemolytic anemia with rituximab. Lancet 2001;358:15113. 10. Zaja F, Iacona I, Masolini P, Russo D, Sperotto A, Prosdocimo S, et al. B-cell depletion with rituximab as treatment for immune hemolytic anemia and chronic thrombocytopenia. Haematologica 2001;87:189-95. 11. van der ...

EACTIONS to the transfusion of blood are ordinarily classified as pyrogenic, allergic or hemolytic. The first two are relatively minor in importance, but hemolytic transfusion reactions, usually due to the use of incompatible blood, are severe and may be lethal. Another type of reaction to whole blood, not previously described, was observed by us in at least ii cases during the past three years...