Tramadol is a veterinary analgesic for dogs. In this study, the steady-state pharmacokinetics of sustained-release (SR) tablet (Tramagetic OD®) and immediate-release capsules (IR) were compared. crossover design, six dogs received five doses IR 50 mg four times day (qid), or two SR 200 once (sid). Eight blood samples collected per dog, formulation, up to 6 24 h after last dose, respectively. Se...

The goal of hormone replacement is to mirror physiology. Hydrocortisone granules and modified release formulations are being developed optimise cortisol in the rare disease adrenal insufficiency. To facilitate clinical development, we built verified a physiologically based pharmacokinetic (PBPK) model for endogenous (hydrocortisone) healthy adults, children adults with predicted immediate-relea...

In the present work, to maintain a suitable blood level of vinpocetine (VP) for a long period of time, VP-cyclodextrin-tartaric acid multicomponent complexes were prepared and formulated in hydroxypropylmethylcellulose matrix tablets. In vitro and in vivo performances of these formulations were investigated over a VP immediate release dosage form. Solubility studies were performed to evaluate t...