BACKGROUND To evaluate the effects on vitrectomy with internal limiting membrane (ILM) peeling versus vitrectomy with inverted internal limiting membrane flap technique for macular hole-induced retinal detachment (MHRD). METHODS Pubmed, Cochrane Library, and Embase were systematically searched for studies that compared ILM peeling with inverted ILM flap technique for macular hole-induced reti...

PURPOSE To compare the anatomic and functional results of 3 different epimacular dissection techniques on macular hole surgery. METHODS Vitrectomy was performed in 123 eyes for macular hole in a retrospective, consecutive case series by one surgeon. The surgical technique was identical except for the method of epimacular dissection, which was performed using 1 of 3 techniques sequentially. Th...

PURPOSE The aims of this study were to analyze optical coherence tomography (OCT) imaging of large macular holes (MHs) treated with inverted internal limiting membrane (ILM) flap technique and to perform a histological examination of an ILM-like membrane tissue obtained during vitrectomy. PATIENTS AND METHODS This is a retrospective observational case study. Nine patients, comprising of five ...

Manuscript received: 18.10.15; Revision accepted: 29.02.16 A 32‐year‐old male presented with 4 weeks history of sudden decrease of vision in his right eye following a bout of cough. The left eye was normal. The anterior segment in the right eye was normal. A dilated fundus of the right eye showed a 6 mm × 4 mm area of premacular hemorrhage [Fig. 1a]. Spectral domain optical coherence tomography...

PURPOSE To evaluate the long-term outcome and safety of vitrectomy for the treatment of an idiopathic macular hole using indocyanine green (ICG) to peel the internal limiting membrane(ILM). SUBJECTS AND METHODS By means of a retrospective study, we evaluated the outcomes of 56 eyes in 56 patients with an idiopathic macular hole who all underwent a primary vitrectomy with successful closure of...

R ecently, enzymatic vitrectomy has been applied to macular hole (MH) repair. A clinical trial indicated that 40% of MH cases could be treated with a single injection of ocriplasmin (Jetrea, ThromboGenics).1 These results are exciting, but the remaining 60% of patients still require surgery, specifically pars plana vitrectomy (PPV) and internal limiting membrane (ILM) peeling for hole repair. I...

Purpose To investigate the mechanism of macular hole (MH) closure following the inverted internal limiting membrane (ILM) technique. Methods We performed the inverted ILM flap surgical technique as an experimental MH model in monkeys, and investigated the process of MH closure immunohistochemically. We then investigated the effects of type IV collagen, fibronectin, and laminin, which are cons...

PURPOSE To determine whether internal limiting membrane (ILM) peeling is effective and cost effective compared with no peeling in patients with idiopathic stage 2 or 3 full-thickness maculay hole (FTMH). METHODS This was a pragmatic multicenter randomized controlled trial. Eligible participants from nine centers were randomized to ILM peeling or no peeling (1:1 ratio) in addition to phacovitr...

PURPOSE To determine the effects of X-linked and autosomal recessive Alport syndrome on retinal basement membranes and how these result in the characteristic perimacular dot-and-fleck retinopathy, lozenge, and macular hole. METHODS The type IV collagen chains present in the normal retina were determined immunohistochemically. Ten patients with Alport syndrome underwent retinal photography and...