INTRODUCTION Rheumatoid arthritis (RA) is an inflammatory disease of the joint characterized by chronic synovitis causing pain, swelling and loss of function due to destruction of cartilage and bone. The complex series of pathological events occurring in RA is largely regulated via excessive production of pro-inflammatory cytokines, the most prominent being tumor necrosis factor (TNF). The obje...

Endometrial cancer (EC) is an increasing health concern, with its growth driven by angiogenic switch that occurs early in development. Our study used publicly available datasets to examine the expression of angiogenesis-related genes and proteins EC tissues, compared them adjacent control tissues. We identified nine significant differential selected six additional antiangiogenic from prior rese...

One purpose of the EC funded project, SPIDIA, is to develop evidence-based quality guidelines for the pre-analytical handling of blood samples for RNA molecular testing. To this end, two pan-European External Quality Assessments (EQAs) were implemented. Here we report the results of the second SPIDIA-RNA EQA. This second study included modifications in the protocol related to the blood collecti...

A well-known result by Kemperman describes the structure of those pairs (A, B) of finite subsets of an abelian group satisfying |A+B| ≤ |A|+ |B| − 1. We establish a description which is, in a sense, dual to Kemperman’s, and as an application sharpen several results due to Deshouillers, Hamidoune, Hennecart, and Plagne. 1. Overview of the paper The sumset of two subsets A and B of an additively ...

BACKGROUND Studies have demonstrated that inflammation has a key role in the pathogenesis of atherosclerosis due to the abnormal gene expressions of multiple cytokines. We established an accurate and precise method to observe gene expression in whole blood that might provide specific diagnostic information for coronary artery disease (CAD) and other related diseases. METHODS The fifteen selec...

The doctrine I am about to explain I have, according to the distinction of Dr. Brown, which I take to be a philosophical one, called a theory. Concerning the difference between an hypothesis and theory, he has said (Phil. Hum. Mind, Lect. 8), "We commonly give the name of hypothesis to cases in which we suppose the intervention of some substance, of the existence of which, as present in the phe...

The proinflammatory chemokine interleukin-8 (IL-8) is undetectable in androgen-responsive prostate cancer cells (e.g., LNCaP and LAPC-4), but it is highly expressed in androgen-independent metastatic cells, such as PC-3. In this report, we show IL-8 functions in androgen independence, chemoresistance, tumor growth, and angiogenesis. We stably transfected LNCaP and LAPC-4 cells with IL-8 cDNA an...

Purpose:We examined whether pretreatment levels of angiogenesisor hypoxia-related proteins and their changes after one cycle of first-line bevacizumab-based therapy were associated with response, PFS, or OS in patients with metastatic breast cancer. Experimental Design:We included 181 patients enrolled in the phase II ATX trial evaluating first-line paclitaxel and bevacizumab without or with ca...