نتایج جستجو برای: il1α
تعداد نتایج: 93 فیلتر نتایج به سال:
Bovine tuberculosis (BTB) is a chronic, highly infectious disease that affects humans, cattle and numerous species of wildlife. In developing countries such as South Africa, the existence of extensive wildlife-human-livestock interfaces poses a significant risk of Mycobacterium bovis transmission between these groups, and has far-reaching ecological, economic and public health impacts. The Afri...
Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease characterized by the selective death of motor neurons. Disease pathophysiology is complex and not yet fully understood. Higher gene expression of the inositol 1,4,5-trisphosphate receptor 2 gene (ITPR2), encoding the IP3 receptor 2 (IP3R2), was detected in sporadic ALS patients. Here, we demonstrate that ...
Complete artificial saliva (CAS) is a saliva substitute often used as a vehicle for test articles, including smokeless tobacco products. In the course of a study employing normal adult human dermal fibroblasts (HDFa) as a model in vitro, we discovered that CAS as a vehicle introduced a significant change in the expression of proinflammatory cytokines. To determine the effects of CAS on gene exp...
PURPOSE Constitutive NF-κB activation is identified in about 70% of pancreatic ductal adenocarcinoma (PDAC) cases and is required for oncogenic KRAS-induced PDAC development in mouse models. We sought to determine whether targeting IL-1α pathway would inhibit NF-κB activity and thus suppress PDAC cell growth. EXPERIMENTAL DESIGN We determined whether anakinra, a human IL-1 receptor (rhIL-1R) ...
THE ROLE OF ALARMINS, INVARIANT NKT CELLS AND SENESCENCE IN THEPATHOPHYSIOLOGY OF STERILE INTRA-AMNIOTIC INFLAMMATIONbyOLESYA PLAZYOAugust 2016Advisor: Nardhy Gomez-Lopez, Ph.D.Major: Physiology (Reproductive Sciences Concentration)Degree: Doctor of PhilosophyPreterm birth is defined as the delivery of a live baby prior to the 37th week ofgestation. It is...
There has been great progress in the 30 y since the reporting in 1984 of the cDNA for interleukin1 (IL1) β in the human and IL1α in the mouse. However, the history of IL1 begins in the early 1940s with investigations into the nature of an endogenous fever-producing protein released rabbit peritoneal neutrophils. Most researchers in immunology today are unaware that the field of cytokines, parti...
Ultraviolet (UV) radiation activates cell signaling pathways in melanocytes. As a result of altered signaling pathways and UV-induced cellular damage, melanocytes can undergo oncogenesis and develop into melanomas. In this study, we investigated the effect of UV-radiation on p38 MAPK (mitogen-activated protein kinase), JNK and NFκB pathways to determine which plays a major role in stimulating T...
Inflammation is necessary for defense against pathogens, but chronic inflammation can promote tumor growth and enable tumors to escape from immune-mediated destruction. Recently, we demonstrated that deficiency of IL1β favors antitumor immunity, multiple clinical trials involving antibody mediated blockade in cancers are underway. We showed IL1α signaling was required blockade-induced leading t...
We conducted a research program focused on infant skin types (normal, dry, sensitive, atopic), using similar in vitro models and non-invasive clinical assessments. All infants had examination, barrier function hydration assessment. Other markers were selected depending types. In mostly based patented age-dependent reconstructed epidermis, customized for each problem, plus an innervated epidermi...
The aim of this study was to investigate the differential gene expression of cytokines in peripheral blood mononuclear cells (PBMCs) from patients with pulmonary embolism (PE) and controls. Twenty patients with PE and twenty control patients matched for gender and age with the PE group were recruited into the study. Human cDNA microarray analysis was used to detect differences in the expression...
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