نتایج جستجو برای: il 21

تعداد نتایج: 382409  

Journal: :Journal of immunology 2007
Yayoi Hiromura Tsunao Kishida Hiroshi Nakano Takemitsu Hama Jiro Imanishi Yasuo Hisa Osam Mazda

Type I allergic diseases such as allergic rhinitis are caused by IgE-mediated humoral immune responses, while eosinophils also fulfill important roles in the etiology of IgE-mediated allergy. IL-21 regulates growth, differentiation, and function of T, B, and NK cells, while the production of IgE is also influenced by IL-21. In this study we examined whether IL-21 is capable of controlling IgE-m...

2002
Akira Suto Hiroshi Nakajima Koichi Hirose Kotaro Suzuki Shin-ichiro Kagami Yohei Seto Aihiro Hoshimoto Yasushi Saito Donald C. Foster Itsuo Iwamoto

Interleukin 21 (IL-21) has recently been identified as a multifunctional cytokine that induces the proliferation of T cells and B cells and differentiation of natural killer cells. To determine whether IL-21 regulates IL-4–mediated immune responses, we examined the effect of IL-21 on antigen-specific IgE production in mice. We also examined the effect of IL-21 on IL-4–induced IgE production fro...

Journal: :Journal of Clinical & Cellular Immunology 2011

2011
Danelle Eto Christopher Lao Daniel DiToro Burton Barnett Tania C. Escobar Robin Kageyama Isharat Yusuf Shane Crotty

Cytokines are important modulators of lymphocytes, and both interleukin-21 (IL-21) and IL-6 have proposed roles in T follicular helper (Tfh) differentiation, and directly act on B cells. Here we investigated the absence of IL-6 alone, IL-21 alone, or the combined lack of IL-6 and IL-21 on Tfh differentiation and the development of B cell immunity in vivo. C57BL/6 or IL-21(-/-) mice were treated...

Journal: :The Journal of Immunology 2009

Journal: :Blood 2009
Stephan Borte Qiang Pan-Hammarström Chonghai Liu Ulrich Sack Michael Borte Ulf Wagner Dagmar Graf Lennart Hammarström

Interleukin-21 (IL-21) is an important promoter for differentiation of human B cells into immunoglobulin (Ig)-secreting cells. The objective of this study was to evaluate an IL-21-based approach to induce immunoglobulin production in B cells from patients with common variable immunodeficiency (CVID) or selective IgA deficiency (IgAD). We show that a combination of IL-21, IL-4, and anti-CD40 sti...

2016
Li Li Yuxia Jiang Suihua Lao Binyan Yang Sifei Yu Yannan Zhang Changyou Wu Angelo A. Izzo

In the current study of Mycobacterium tuberculosis (MTB)-specific T and B cells, we found that MTB-specific peptides from early secreted antigenic target-6 (ESAT-6) and culture filtrate protein-10 (CFP-10) induced the expression of IL-21 predominantly in CD4(+) T cells. A fraction of IL-21-expressing CD4(+) T cells simultaneously expressed Th1 cytokines but did not secrete Th2 or Th17 cytokines...

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