Although tumor-associated abnormal glycosylation has been recognized for decades, information regarding host recognition of the evolving tumor glycome remains elusive. We report here a carbohydrate microarray analysis of a number of tumor-associated carbohydrates for their serum antibody reactivities and potential immunogenicity in humans. These are the precursors, cores and internal sequences ...

 In this research, a tri-objective mathematical model is proposed for the Transportation-Location-Routing problem. The model considers a three-echelon supply chain and aims to minimize total costs, maximize the minimum reliability of the traveled routes and establish a well-balanced set of routes. In order to solve the proposed model, four metaheuristic algorithms, including Multi-Objective Gre...

Gen_spectrum=Generic_1nm_Interpolation(Input_Spectrum, Method=’Cubic Splines’) First_filt_step=Filter_Boxcar(Gen_Spectrum, boxcar_length=’10% of Gen_spectrum’) Second_filt_step=Filter_Boxcar(First_filt_step, boxcar_length=’10% of Gen_spectrum’) Third_filt_step=Filter_Boxcar(Gen_Spectrum, boxcar_length=’2% of Gen_spectrum’) Fourth_filt_step=Filter_Boxcar(Third_filt_step, boxcar_length=’2% of Gen...

This research investigates a practical bi-objective model for the facility location–allocation (BOFLA) problemwith immobile servers and stochastic demand within the M/M/1/K queue system. The first goal of the research is to develop a mathematical model in which customers and service providers are considered as perspectives. The objectives of the developed model are minimization of the total cos...

Synthesis of a ligand platform to generate di- and tri-mesoionic carbenes is reported together with their multinuclear Pd(II) complexes. Complete structural characterization and preliminary electrochemical data are presented.

The U4/U6.U5 tri-snRNP is a key component of spliceosomes. By using chemical reagents and RNases, we performed the first extensive experimental analysis of the structure and accessibility of U4 and U6 snRNAs in tri-snRNPs. These were purified from HeLa cell nuclear extract and Saccharomyces cerevisiae cellular extract. U5 accessibility was also investigated. For both species, data demonstrate t...

Automatic steering systems have been available for several years. Mechanical feeler systems, including the Tri-R system2, can provide moderate performance at a reasonable cost, but face limitations (Figure 1). Mechanical feel systems are crop limited and require a relatively stiff crop that has reached sufficient maturity for the feeler to detect. The feeler systems are both speed and curve lim...

DAZ is an RNA-binding protein encoded by a region on the Y chromosome implicated in infertility, and DAZ-like (Dazl) proteins are master regulators of germ line gene expression in all animals. In mice Dazl is only expressed in germ cells and is necessary for meiosis. A dual approach was taken to understand the RNA-binding specificity of the Dazl protein: (i) traditional SELEX and (ii) a novel t...