Physical properties of over 8000 intramolecular hydrogen bonds (iHBs), including 2901 ones of the types OH···O, OH···N, NH···O and OH···C, in 4244 conformers of the DNA-related molecules (four canonical 2'-deoxyribonucleotides, 1,2-dideoxyribose-5-phosphate, and 2-deoxy-D-ribose in its furanose, pyranose and linear forms) have been investigated using quantum theory of atoms in molecules (QTAIM)...

Abstract Background Prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) is increasing in patients with Inflammatory Bowel (IBD), particularly Crohn's (CD). Despite this, the mechanisms and risk factors NAFLD IBD are still poorly understood controversial. The aim this study was to assess prevalence for CD. Methods Prospective conducted among consecutive CD treated at Diseases outpatient clin...

Halogen bonding (XB) non-covalent interactions can be observed in compounds containing chlorine, bromine, or iodine which can form directed close contacts of the type R1-XY-R2, where the halogen X acts as a Lewis acid and Y can be any electron donor moiety including electron lone pairs on hetero atoms such as O and N, or π electrons in olefin double bonds and aromatic conjugated systems. In thi...

Late in October 1926, a poor man from Bucamaranga, Colombia, wrote a letter to the richest man in the world. Juan de la Rosa Quintero Parra informed John D Rockefeller that his ten-year-old son, José Vicente, had “died suddenly as a result of a purge administered by the Bureau of Uncinariasis”, the local incarnation of the Rockefeller Foundation’s global project to eradicate hookworm disease. T...

10 Simes JR, Weaver DW, Ellis SG, Grines CL. Overview of the randomised trials of primary PTCA and thrombolysis in acute myocardial infarction [abstract]. Circulation 1997;94(suppl):I33 1. 11 ISIS-3 collaboration group. A randomised comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41,299 cases of suspected acute myoca...

Abstract Background Inflammatory bowel disease (IBD) commonly affects women and men during the reproductive years.The effect of burden on fertility in these patients is a common concern for them. ECCO guidelines establish that active associated with decreased but studies regarding this topic are low quality outdated. Aims to investigate CD fertility, studying ovarian reserve as well global Sert...

Resonance lines broadened by dipolar interactions are a common phenomenon. The best studied cases are the nuclear magnetic resonance lines, for which Van Vleck's [ 1 ] classic analysis gives expressions for the moments of the shape. Recently work on muon spin resonance [2,3] stimulated questions of whether the linewidth depended on the number n of sites over which the muon moved coherently. Yao...

The successful demonstration that insulin-producing -cells can be isolated (in the form of cell clusters called islets containing and other endocrine and nonendocrine cells) from a recently deceased donor’s pancreas, then transplanted into subjects with type 1 diabetes, and thereby restore, at least temporarily, insulin-independent normoglycemia has firmly established the important “proof of co...

While differentiating T-cell autoreactivity against pancreatic islets between type 1 diabetic patients and nondiabetic control subjects has, over time, proven to be a difficult task, the ultimate challenge for cellular markers of this disease will involve the definition of immunological measures associated with disease progression and intervention. With the notion that type 1 diabetes is a T-ce...

This introductory investigation into the human resource implications associated with the tensions between integration and responsiveness studied the concept of International Human Resource (IHR) Strategy; its dimensions and its determinants. To accomplish this, Jarillo and Martinez's (1990) parent--subsidiary business strategy framework was recast in an IHR strategy setting. Then, the relations...