نتایج جستجو برای: ige
تعداد نتایج: 15371 فیلتر نتایج به سال:
conclusions the characteristic features of ige-mediated food allergy are abrupt onset of clinical symptoms, which may result in a life-threatening events, and positive results of the majority of the paraclinical tests that mainly trace the specific ige to foods. moreover, non–ige-mediated food allergies present as chronic diseases and due to lack of proper diagnostic tests the similarity of the...
Serum IgE concentrations were determined and IgE turnover studies were performed in control individuals as well as in patients with several disease states. Patients with common variable hypogammaglobulinemia, thymoma and hypogammaglobulinemia, ataxia telangiectasia, and selective IgA deficiency had significantly decreased mean serum IgE concentrations. In turnover studies, this was found to be ...
The manifestations of allergic disorders are closely tied to the biologic effects of IgE activation with Ag. In immediate hypersensitivity reactions, IgE effector function requires prior binding to innate immune cells, primarily mast cells and basophils, with the blood acting as a reservoir for unbound IgE. As the severity of allergic disease is proportional to the size of this unbound IgE pool...
Omalizumab is a widely used therapeutic anti-IgE antibody. Here we report the crystal structure of the omalizumab-Fab in complex with an IgE-Fc fragment. This structure reveals the mechanism of omalizumab-mediated inhibition of IgE interactions with both high- and low-affinity IgE receptors, and explains why omalizumab selectively binds free IgE. The structure of the complex also provides mecha...
مقدمه: در ارزیابی افراد مبتلا به بیماریهای آلرژیک، تعیین مقدار ایمونوگلوبولین ها نظیر ige ضروری به نظر می رسد. عوامل مختلفی مانند: سن، جنس، نژاد، و وضعیت آتوپیک در غلظت ige مؤثر شناخته شده اند. هدف این مطالعه ارزیابی غلظت ige سرم در برخی افراد ساکن تهران می باشد.روش کار: ige سرم با استفاده از کیت الایزا (eia-gen biochem-italy) در 267 فرد ظاهراً سالم غیر آتوپیک و غیر سیگاری (195 زن، و 72 مرد) و 1...
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