نتایج جستجو برای: ifnl3

تعداد نتایج: 233  

2015
Scott A. Read Enoch S. Tay Mahsa Shahidi Kate S. O’Connor David R. Booth Jacob George Mark W. Douglas Naglaa H. Shoukry

Treatment of chronic hepatitis C virus (HCV) infection is evolving rapidly with the development of novel direct acting antivirals (DAAs), however viral clearance remains intimately linked to the hepatic innate immune system. Patients demonstrating a high baseline activation of interferon stimulated genes (ISGs), termed interferon refractoriness, are less likely to mount a strong antiviral respo...

Journal: :Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 2016
Adina Maria Kamal Paul MitruŢ Kamal Constantin Kamal Oana Sorina Tica Mihaela Niculescu Dragoş Ovidiu Alexandru Andrei Adrian Tica

Globally, over 4% of the world population is affected by hepatitis C virus (HCV) infection. The current standard of care for hepatitis C infection is combination therapy with pegylated interferon and ribavirin for 48 weeks, which yield a sustained virological response in only a little over half of the patients with genotype 1 HCV. We investigated the clinical importance of pharmacogenetics in t...

Journal: :hepatitis monthly 0
jacqueline k flynn centre for biomedicine, burnet institute, melbourne, australia; department of infectious diseases, monash university, melbourne, australia; centre for biomedicine, burnet institute, 3001 victoria, g.p.o. box: 2284, melbourne, australia. tel: +61-392822109, fax: +61-392822100 rachel sacks-davis centre for population health, burnet institute, melbourne, australia; department of epidemiology and preventive medicine, monash university, melbourne, australia peter higgs centre for population health, burnet institute, melbourne, australia; department of epidemiology and preventive medicine, monash university, melbourne, australia; national drug research institute, faculty of health sciences, curtin university, melbourne, australia campbell aitken centre for population health, burnet institute, melbourne, australia; department of epidemiology and preventive medicine, monash university, melbourne, australia sarah moneer department of microbiology and immunology, university of melbourne, parkville, australia vijay suppiah storr liver unit, westmead millennium institute, university of sydney, sydney, australia; school of pharmacy, university of south australia, adelaide, australia

conclusions this study demonstrated the detection of hcv-specific ifn-γ responses in hcv antibody and rna negative individuals, with a tendency for hcv-specific ifn-γ responses to be associated with hcv exposure. the potential role of hcv-specific ifn-γ responses in those who remained hcv rna negative is of value for the development of novel hcv therapeutics. objectives in a cohort of hcv antib...

Journal: :Nephrology Dialysis Transplantation 2023

Abstract Background and Aims A recent study from a large cohort published by the Ubiquitous Pharmacogenomic Consortium demonstrates interest of pre-emptive pharmacogenetic panel testing, with 30% reduction rate clinically detectable side-effects. Our laboratory routinely performs diagnostic exome sequencing (ES) for adult patient kidney disease more than 2000 patients have been analyzed to date...

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