Background Previous work suggests that major depressive disorder (MDD) is associated with disturbances in global connectivity among brain regions, as well as local connectivity within regions. However, the relative importance of these global versus local changes for successful antidepressant treatment is unknown. We used multiscale entropy (MSE), a measure of brain signal variability, to examin...

Breast cancer is the leading cause of new cancer diagnoses among women. Using peroxisome proliferator-activated receptor (PPAR)γ((+/-)) mice, we showed normal expression of PPARγ was critical to stop 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast tumorigenesis. PPARγ is expressed in many breast cell types including mammary secretory epithelial (MSE) cells. MSEs proliferate as required dur...

Melinjo (Gnetum gnemon L.) seed extract (MSE) containing trans-resveratrol (3,5,4'-trihydroxy-trans-stilbene) and other derivatives exerts various beneficial effects. However, its mechanism of action in humans remains unknown. In this study, we aimed to investigate beneficial effects of MSE in healthy adult males. In this double-blind, randomized controlled study, 30 males aged 35-70 years with...

Abstruct-Rate of convergence results are established for vector quantization. Convergence rates are given for an increasing vector dimension and/or an increasing training set size. In particular, the following results are shown for memoryless realvalued sources with bounded support at transmission rate R: (1) If a vector quantizer with fixed dimension k is designed to minimize the empirical mea...

Aims and method To investigate medical students' performance at and perceptions of the mental state examination (MSE) at a medical school with a modern integrated curriculum. We undertook an evaluative case study comprising a survey and analysis of performance data. The study is presented in two parts: part 1 discusses the students' perceptions of the MSE and the teaching, learning and practisi...

In this paper, a relationship between Linear Discriminant Analysis (LDA) and the generalized Minimum Squared Error (MSE) solution is presented. The generalized MSE solution is shown to be equivalent to applying a certain classification rule in the space defined by LDA. The relationship between the MSE solution and Fisher Discriminant Analysis (FDA) is extended to multi-class problems and also t...

The convergence of communications and information technology within education, as well as more widely, means that concepts developed within ITS & AIED are now applicable to a wider range of wired, and more interestingly 'wireless', technologies. Interactive TV, supported by broadband broadcasting, offers interesting possibilities for education. The use of TV (and radio) in education has a long ...

We survey the evaluation methodology adopted in Information Extraction (IE), as defined in the MUC conferences and in later independent efforts applying machine learning to IE. We point out a number of problematic issues that may hamper the comparison between results obtained by different researchers. Some of them are common to other NLP tasks: e.g., the difficulty of exactly identifying the ef...