Although herpes simplex virus (HSV) replicates in noncycling as well as cycling cells, including terminally differentiated neurons, it has recently been shown that viral replication requires the activities of cellular cyclin-dependent kinases (cdks) (L. M. Schang, J. Phillips, and P. A. Schaffer, J. Virol. 72:5626-5637, 1998). Since we were unable to isolate HSV mutants resistant to two cdk inh...

A seven- to eightfold increment in hepatic glucose production (endogenous R(a)) occurs in postabsorptive (PA) intense exercise (IE). A similar response is likely present in the postprandial (PP) state, when most such exercise is performed, because 1) little evidence for increased intestinal absorption of glucose during exercise exists, and 2) intravenous glucose does not prevent it. We investig...

Infective endocarditis (IE) usually is studied using animals with catheters inserted into the heart, which causes formation of platelet-fibrin thrombi (vegetations, VGs). We used two rabbit models to study the respective roles of the catheter and the VGs in the development of IE. The influence of the catheter was studied by either removing the catheter before bacterial challenge, or leaving the...

The findings of clinical and in vitro research support the theory that infective endocarditis (IE)-causing bacteria form biofilms and that biofilms negatively affect treatment outcomes. The purpose of the present study was to quantify the biofilm formation of methicillin (meticillin)-resistant Staphylococcus aureus (MRSA) isolates obtained from patients with IE and to evaluate the in vitro acti...

background: molecules expressed on the surface of infected erythrocytes (ie) with plasmodium falci-parum play important roles in malaria pathogenesis and immune evasion. some of these molecules are specific adhesive ligands mediating adhesion of ie to the vascular endothelium. in the current study, the antigens exposed on the surface of ie with different isolates and various binding subpopulati...

Hematologic evaluation via CBC—including automated analysis and manual blood smear evaluation—is routine for wellness health screening and diagnostic evaluation in clinically ill patients. Observed abnormalities typically indicate an underlying disease process; however, many breed-associated hematologic anomalies are not associated with clinical disease. These takeways are important to avoid mi...

this article elaborates on the experience of higher medical education evaluation in iran. although institutional evaluation in iran started in about a decade ago, recent policies of the government to increase quality of higher medical education have contributed to a special effort in designing and implementing evaluation mechanisms in university systems in iran. among these a process of interna...

background:   primary bone lymphoma or non-hodgkin lymphoma of bone is a rare disease. there are only a few case series of stage ie of this condition in medical literature. the aim of this study is to determine the rate of survival   for stage ie after combined modality treatment, the rate of local recurrence, and the results of limb salvage in cases   of local recurrence.     methods:   we col...

Z u r U n tersuchung d e r K o m p lex b ild u n g zwischen P o ly m o ly b d a tio n en u n d P e r jo d sä u re bzw . N a triu m ­ p e r jo d a t b ie ten sich zw ei p rin z ip ie ll verschiedene U n tersuchungsm öglichkeiten an , um zu A ussagen ü b e r A rt, G röße u n d B estän d ig k e it d e r K om plex­ ionen in L ösung zu k o m m e n : 1. E ine p rä p a ra tiv e U n te rs u c h u n g 1...