Abstract Study question To what extent do genomic variants contribute to idiopathic recurrent pregnancy loss (RPL)? Summary answer Pathogenic uniparental disomy, copy number variations, and single nucleotide were identified in 18 of 83 couples their embryos/fetuses with RPL. What is known already RPL defined as the two or more pregnancies before 24 weeks gestation. The etiologies include antiph...

background recurrent pregnancy loss (rpl) is a serious problem for pregnancy. there is evidence that vascular complications play a principal role in rpl. methylenetetrahydrofolate reductase (mthfr) is a key enzyme in folate metabolism. polymorphisms (c677t, a1298c) of mthfr gene are associated with decreased mthfr activity. objectives the aim of this study was to determine the association betwe...

BACKGROUND Idiopathic secondary recurrent miscarriage may be associated with an abnormal maternal immune response to subsequent pregnancies. Intravenous immunoglobulin (IVIG) has been studied in randomized controlled trials (RCTs) with conflicting results. Therefore, a definitive trial was proposed. METHODS We conducted an investigator-initiated, multicentered, randomized, double-blinded, pla...

Recurrent pregnancy loss is an important reproductive health issue, affecting 2%-5% of couples. Common established causes include uterine anomalies, antiphospholipid syndrome, hormonal and metabolic disorders, and cytogenetic abnormalities. Other etiologies have been proposed but are still considered controversial, such as chronic endometritis, inherited thrombophilias, luteal phase deficiency,...

Spontaneous abortion (SAB) is defined as the expulsion of a fetus before 20 weeks of gestation or weighing less than 500 g.’ Losses after 20 weeks are described as stillbirths or premature births and, generally, have different etiologies than losses earlier in gestation. The vast majority of SABs occur before 12 weeks of gestation. Those occurring at less than 8 weeks often do not contain an em...

In recent decades, the association between a hypercoagulable state and its causes and adverse pregnancy outcome, in particular recurrent pregnancy loss (RPL) has been studied extensively. Although the first studies were focused only on the association between thrombophilia and RPL, subsequent studies underlined also a potential role of antithrombotic treatment to prevent vascular complication s...