Lethal Toxin Neutralizing Factor (LTNF) obtained from Opossum serum (Didephis virginiana) is known to exhibit toxin-neutralizing activity for envenomation caused by animals, plants and bacteria. Small synthetic peptide- LT10 (10mer) derived from N-terminal fraction of LTNF exhibit similar anti-lethal and anti-allergic property. In our in silico study, we identified Insulin Degrading Enzyme (IDE...

The effects of exercise on insulin clearance and IDE expression are not yet fully elucidated. Here, we have explored the effect of acute exercise on insulin clearance and IDE expression in lean mice. Male Swiss mice were subjected to a single bout of exercise on a speed/angle controlled treadmill for 3-h at approximately 60-70% of maximum oxygen consumption. As expected, acute exercise reduced ...

We aimed to study the response of serum transferrin receptors (sTfR) to Fe supplementation in women of childbearing age with Fe-deficiency erythropoiesis (IDE) and Fe-deficiency anaemia (IDA). Primary screening was performed in 942 women ranging in age from 18 to 45 years. After Fe-related biochemical indices such as serum ferritin, Zn protoporphyrin and Hb were determined, the subjects were di...

The development of atherosclerotic lesions and abdominal aortic aneurysms involves degradation and loss of extracellular matrix components, such as collagen and elastin. Releases of the elastin cross-links desmosine (DES) and isodesmosine (IDE) may reflect elastin degradation in cardiovascular diseases. This study investigated the production of soluble elastin cross-linking structures by protei...

The computing industry has yet to take up agent technology as a new approach to software development. While other paradigms are supported by various tools, including generic IDEs, these are not well developed for agentware. Many agent platforms provide some form of IDE but these are platformspecific and are typically so tightly coupled to their agent platforms that they offer little re-use. The...

According to the amyloid hypothesis, Abeta peptides are neurotoxic and underlie development and progression of Alzheimer's disease (AD). Multiple Abeta clearance mechanisms, including destruction of the peptides by proteolytic enzymes, are hypothesized to regulate physiological Abeta peptide levels. The insulin-degrading enzyme (IDE) is considered one of the predominant enzymes having Abeta deg...

The aim of this study was to evaluate in vitro the permeation of the antioxidant agent Idebenone (IDE) loaded into solid lipid nanoparticles (SLN) across MDCKII-MDR1 cell monolayer, selected as an in vitro model of the Blood Brain Barrier (BBB). SLN were prepared using cetyl palmitate as solid lipid and different non-ionic surfactants, oleth-20, ceteth-20 and isoceth-20, by the phase inversion ...

The Java-based Hume IDE provides a classic edit/run/debug text-based interactive programming environment, augmented with the Hume Diagram Tool(HDT) which displays two-dimensional box/wiring diagrams from Hume source programs. Diagram layout may be modified interactively and wires may be inspected to identify associated types. Here, we present an overview of the IDE, focusing on the HDT. We also...

In this paper, we describe an IDE called CAPS (Calculational Assistant for Programming from Specifications) for the interactive, calculational derivation of imperative programs. In building CAPS, our aim has been to make the IDE accessible to non-experts while retaining the overall flavor of the pen-and-paper calculational style. We discuss the overall architecture of the CAPS system, the main ...

Spoofax is a language workbench for efficient development of textual domain-specific languages together with state-of-the-art IDE support. Spoofax integrates language and IDE development into a single environment, using concise, declarative specifications for languages and IDE services. We are extending Spoofax with a framework for the implementation of refactorings. The current paper gives an ...