One striking feature of spontaneous autoimmune diabetes is the prototypic formation of lymphoid follicular structures within the pancreas. Lymphotoxin (LT) has been shown to play an important role in the formation of lymphoid follicles in the spleen. To explore the potential role of LT-mediated microenvironment in the pathogenesis of insulin-dependent diabetes mellitus (IDDM), an LTbeta recepto...

HLA-DR4, Dw4-associated haplotypes associated with IDDM and JRA were compared using genomic DNA restriction fragment analysis to distinguish among DQ beta and alpha alleles linked to DR4. DQ beta polymorphisms that subdivide the HLA-DQw3 specificity into DQ3.1 and 3.2 alleles were identified. More than 90% of DR4+ IDDM patients express one of these alleles, DQ3.2; restriction enzyme mapping ind...

Introduction: Insulin dependant diabetes mellitus (IDDM) is an autoimmune disease that disrupts the body’s ability to produce insulin, and thus regulate the level of glucose in the blood. IDDM is associated with numerous systemic complications, including the impairment of fracture healing. Common problems include delayed unions, non-unions, and pseudoarthrosis. Previous studies conducted in our...

OBJECTIVE To investigate whether girls with insulin dependent diabetes mellitus (IDDM) were more overweight than nondiabetic girls, and how diet, insulin treatment, metabolic control, age, and pubertal status were related to body weight and fat content. DESIGN Case-control study. SUBJECTS AND METHODS 48 IDDM girls aged 10-19 years and controls matched for age and social class participated i...

Persons with conventionally treated insulin-dependent diabetes mellitus (IDDM) appear to be impaired in their ability to reduce fed-state urea production appropriately in response to dietary protein restriction (Hoffer LJ, Taveroff A, and Schiffrin A. Am J Physiol 272: E59-E67, 1997). To determine whether these conclusions apply to whole body sulfur amino acid (SAA) catabolism, we used samples ...

Programmed cell death represents an important pathogenic mechanism in various autoimmune diseases. Type I diabetes mellitus (IDDM) is a T cell-dependent autoimmune disease resulting in selective destruction of the beta cells of the islets of Langerhans. beta cell apoptosis has been associated with IDDM onset in both animal models and newly diagnosed diabetic patients. Several apoptotic pathways...

We have previously shown that nonobese diabetic (NOD) mice are selectively deficient in alpha/beta-T cell receptor (TCR)+CD4-CD8- NKT cells, a defect that may contribute to their susceptibility to the spontaneous development of insulin-dependent diabetes mellitus (IDDM). The role of NKT cells in protection from IDDM in NOD mice was studied by the infusion of thymocyte subsets into young female ...

Two tubeless tests of exocrine pancreatic function, the NBT-PABA test and faecal chymotrypsin (FCT) assay were compared. Thirteen patients with Fibrocalculous Pancreatic Diabetes (FCPD), 12 patients with Insulin Dependent Diabetes Mellitus (IDDM) and 13 control subjects were studied. Using a PABA excretion value < 43%, 100% of FCPD patients and 58.3% of IDDM patients had abnormal exocrine pancr...

OBJECTIVE To determine whether children with insulin-dependent diabetes mellitus (IDDM) process information more slowly than children who do not have diabetes. METHODS We tested 31 children with early onset and longer duration of IDDM, 35 with later onset and briefer duration of IDDM, and 36 comparison children without diabetes. They were administered five tasks requiring rapid responding tha...

T cells play a major role in the development of insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice. Administration of interleukin 12 (IL-12), a key cytokine which guides the development of T helper type 1 (Th1) CD4+ T cells, induces rapid onset of IDDM in NOD, but not in BALB/c mice. Histologically, IL-12 administration induces massive infiltration of lymphoid cells, mos...