The experimental animals were implanted with two bipolar electodes, one in the lateral hypothalamus including medial forebrain bundle (LH-MFB) and other in ipsilateral ventral tegmental area-substantia nigra (VTA-SN) and were trained to press a pedal for self-stimulation. This provided the scope to compare directly the effect of a given dose of a drug on the two reward regions in the same anima...

BACKGROUND A clinical model is needed to compare inhaled corticosteroids (ICSs) with respect to efficacy. OBJECTIVE The purpose of this investigation was to compare the relative beneficial and systemic effects in a dose-response relationship for 2 ICSs. METHODS A 24-week, parallel, open-label, multicenter trial examined the benefit-risk ratio of 2 ICSs in persistent asthma. Benefit was asse...

In this study, we have investigated sudden changes in volatility and re-examined the persistence of volatility in Japanese and Korean stock markets during 1986–2008. Using the iterated cumulative sums of squares (ICSS) algorithm, we have determined that the identification of sudden changes is generally associated with global financial and political events. We have also demonstrated that control...

This paper studies the impact of COVID-19 on China’s capital market and major industry sectors via an improved ICSS algorithm, a time series model with exogenous variables nonparametric conditional probability estimation. Through empirical analysis stock market, bond different sectors, it is found that pandemic has had no significant return markets; however, increased volatility. There are diff...

This paper addresses the problem of planning data collection missions for a set of Information Collection Systems (ICS) to respond to a set of information requests. This problem goes from the formalization of information needs to the optimization of ICS actions. After having formalized requests and decomposed them into elementary requests, the problem can be modeled with a graph characterizing ...

Impactful academic research plays a stellar role in society, pressing to ask the question of how one measures the impact created by different areas of academic research. Measuring the societal, cultural, economic and scientific impact of research is currently the priority of the National Science Foundation, European Commission and several research funding agencies. The recently concluded United...

Endogenous opioids seem to play a critical role in the regulation of mood states. For example, there is accumulating evidence that stimulation of kappa-opioid receptors, upon which the endogenous opioid dynorphin acts, can produce depressive-like behaviors in laboratory animals. Here we examined whether systemic administration of salvinorin A (SalvA), a potent and highly selective kappa-opioid ...