OBJECTIVE Dementia is a common clinical presentation among older adults with Down syndrome. The presentation of dementia in Down syndrome differs compared with typical Alzheimer's disease. The performance of manualised dementia criteria in the International Classification of Diseases (ICD)-10 and Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revision (DSM-IV-TR) is uncertain in ...

BACKGROUND Patients with nonischemic dilated cardiomyopathy are at substantial risk for sudden death from cardiac causes. However, the value of prophylactic implantation of an implantable cardioverter-defibrillator (ICD) to prevent sudden death in such patients is unknown. METHODS We enrolled 458 patients with nonischemic dilated cardiomyopathy, a left ventricular ejection fraction of less th...

BACKGROUND Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a major cause of ventricular tachycardia (VT) and cardiac arrest in young patients. We hypothesized that treatment with implantable cardioverter/defibrillators (ICDs) is safe and improves the long-term prognosis of ARVC patients at high risk of sudden death. METHODS AND RESULTS Sixty patients with ARVC (aged 43+/-16 years) w...

Moss, E. and Lee, W. R. (1974). British Journal of Industrial Medicine, 31, 224-232. Occurrence of oral and pharyngeal cancers in textile workers. The occupations of male textile workers who died of oral and pharyngeal cancers in the five years 1959-63 have been examined to discover whether the high incidence of oral cancer in these workers noted by the Office of Population Censuses and Surveys...

Correspondence to: Dr Anthony W C Chow, The Heart Hospital, UCLH NHS Trust, 16–18 Westmoreland Street, London W1G 8PH, UK; anthony.chow@uclh. nhs.uk _________________________ T he definition of sudden cardiac death (SCD) remains controversial. Many such deaths are not witnessed, and without cardiac monitoring at the time of death the assumption of an underlying arrhythmic cause is speculative. ...

BACKGROUND In 1992, the ICD-10 introduced the concept of mixed anxiety-depression disorder (MAD). However, a study examining the stability of this ICD-10-diagnosis is lacking. Our objective was to examine the 12 month outcome of MAD in comparison to the outcome of depression, anxiety, and comorbid depression and anxiety. METHODS 85 MAD patients, 496 patients with major depression, 296 patient...