Abstract Purpose Immune-checkpoint-blocker (ICB) associated myocarditis (ICB-myocarditis) may present similarly and/or overlap with other cardiac pathology including acute coronary syndrome presenting a challenge for prompt clinical diagnosis. Methods An international registry was used to retrospectively identify cases of ICB-myocarditis. Presence artery disease (CAD) defined as stenosis &g...

Links between impulsive-compulsive behaviors (ICBs) in treated Parkinson's disease (PD), behavioral addictions, and substance abuse have been postulated, but no direct comparisons have been carried out so far. We directly compared patients with PD with and without ICBs with illicit drug abusers, pathological gamblers, and age-matched healthy controls using the beads task, a test of reflection i...

The cleavage pattern of the black tiger shrimp Penaeus monodon was analyzed from the first division until gastrulation. Observations were based on microscopy combined with the use of fluorescent dyes, histological techniques, and computer based three-dimensional reconstructions. Early cleavage is holoblastic and follows a stereotypic pattern, which largely corresponds to what is known from othe...

We investigated the protective effects and mechanisms of chitosan oligosaccharides (COS) on experimental autoimmune anterior uveitis (EAAU) in rats. EAAU was induced in Lewis rats by footpad and intraperitoneal injections of melanin-associated antigen. The rats received intraperitoneal injections of low-dose (5 mg/kg) or high-dose (10 mg/kg) COS or PBS daily after the immunization. The effects ...

Immune checkpoint blockers (ICB) have emerged as a promising new class of antitumor agents which significantly change the treatment landscape in a range of tumors; however, cancer patients benefited from ICB-based immunotherapy remains limited, scoring the need to explore the combination treatments with synergistic mechanisms of action. Axl receptor tyrosine kinase critically involves in the ca...

A study on the removal of arsenic from real life groundwater using iron-chitosan composites is presented. Removal of arsenic(III) and arsenic(V) was studied through adsorption at pH 7.0 under equilibrium and dynamic conditions. The equilibrium data were fitted to Langmuir adsorption models and the various model parameters were evaluated. The monolayer adsorption capacity from the Langmuir model...

Respiratory Sinus Arrhythmia (RSA), usually the high frequency (HF) component of heart rate variability (HRV), is a cardiorespiratory interaction mediated by the vagus nerve. RSA is thus considered a marker of the parasympathetic modulation of heart rate. Previous studies reported decrease in RSA after spaceflight. Whether this can be due to autonomic adaption to microgravity or only result fro...

The Long Life (Lithium Ion) Battery (LLB/LIB) is designed to replace the current Extravehicular Mobility Unit (EMU) Silver/Zinc (Ag/Zn) Increased Capacity Battery (ICB), which is used to provide power to the Primary Life Support Subsystem (PLSS) during Extravehicular Activities (EVAs). The LLB (a battery based on commercial lithium ion cell technology) is designed to have the same electrical an...

BACKGROUND The aim of this study was to determine the minimum effective volume of lidocaine 1.5% with epinephrine 5 μg/mL in 90% of patients (MEV(90)) for single-injection ultrasound-guided infraclavicular block (ICB). METHODS Using an in-plane technique, a single-injection ultrasound-guided ICB was performed: a 17-gauge, 8-cm Tuohy needle was advanced until the tip was located dorsal to the ...

Recent progress in the treatment of advanced melanoma has led to improved survival affected patients. However, novel treatments also lead considerable and distinct skin toxicity. To further characterize cutaneous adverse events (AE) systemic treatments, we conducted a single-center retrospective study biopsy-proven over period 10 years at University Hospital Zurich, Switzerland. In 102 identifi...