hDlg, a human homologue of the Drosophila Dig tumor suppressor, contains two binding sites for protein 4.1, one within a domain containing three PSD-95/Dlg/ZO-1 (PDZ) repeats and another within the alternatively spliced I3 domain. Here, we further define the PDZ-protein 4.1 interaction in vitro and show the functional role of both 4.1 binding sites in situ. A single protease-resistant structure...

We determine the mean number of 3-torsion elements in the class groups of quadratic orders, where the quadratic orders are ordered by their absolute discriminants. Moreover, for a quadratic order O we distinguish between the two groups: Cl3(O), the group of ideal classes of order 3; and I3(O), the group of ideals of order 3. We determine the mean values of both |Cl3(O)| and |I3(O)|, as O ranges...

Two field experiments were carried out at the village ten, Abu Humus, El-Beheira Governorate, Egypt, during two successive seasons 2016/2017 and 2017/2018, to evaluate effect of three types herbicide irrigation intervals on productivity quality onion cultivar (Giza Red). The designed as split plot in randomized complete block design with replications. Irrigation – (I1) 20 days, (I2) 30 (I3) 40 ...

Water stress may affect the growth, physiology, morphology, biochemistry, and productivity of Nigella sativa (black cumin), a medicinal aromatic plant. Measuring these parameters under various irrigation regimes could provide useful information for successful genotype selection breeding. Therefore, agronomically significant features were evaluated in ten black cumin genotypes (Afghanistan, Paki...

Plastic mulched ridge-furrow irrigation is a useful method to improve crop productivity and decrease salt accumulation in arid saline areas. However, inappropriate fertilizer practices may result ecological environmental problems. In order the resource use efficiency these areas, we investigated effects of different amounts (400 (I1), 300 (I2) 200 (I3) mm) nitrogen application rates (300 (F1) 1...

Abstract. If a tensor with various symmetries is properly unfolded, then the resulting matrix inherits those symmetries. As tensor computations become increasingly important it is imperative that we develop efficient structure preserving methods for matrices with multiple symmetries. In this paper we consider how to exploit and preserve structure in the pivoted Cholesky factorization when appro...

What are the mechanisms of multifunctionality, i.e. the use of the same peripheral structures for multiple behaviors? We studied this question using the multifunctional feeding apparatus of the marine mollusk Aplysia californica, in which the same muscles mediate biting (an attempt to grasp food) and swallowing (ingestion of food). Biting and swallowing responses were compared using magnetic re...

OBJECTIVE To compare the efficacy and safety of continuous terbinafine with intermittent itraconazole in the treatment of toenail onychomycosis. DESIGN Prospective, randomised, double blind, double dummy, multicentre, parallel group study lasting 72 weeks. SETTING 35 centres in six European countries. SUBJECTS 496 patients aged 18 to 75 years with a clinical and mycological diagnosis of d...

To survive, animals must use the same peripheral structures to perform a variety of tasks. How does a nervous system employ one muscle to perform multiple functions? We addressed this question through work on the I3 jaw muscle of the marine mollusk Aplysia californica's feeding system. This muscle mediates retraction of Aplysia's food grasper in multiple feeding responses and is innervated by a...