Despite its abuse potential, nicotine, acting on nicotinic acetylcholine receptor, has possible medicinal uses, in particular in treating neuro degenerative diseases. Therefore, animal models to evaluate exposure need to be characterized. Administration via drinking water is a stressfree route of administration but often results in low blood nicotine levels. Here we evaluated chronic exposure t...

Egr-1 is a transcription factor that couples short-term changes in the extracellular milieu to long-term changes in gene expression. In cultured endothelial cells, the Egr-1 gene has been shown to respond to a variety of extracellular signals. However, the physiological relevance of these findings remains unclear. To address this question, the growth factor-mediated response of the Egr-1 gene u...

Introduction: Determination of thyrotropin, total and free thyroxine and triiodothyronine are widely used as diagnostic methods for thyroid function evaluation. There have been numerous reports of interferences in thyroid hormone immunoassays. Herein, a prominent positive interference is reported for a radioimmunoassay kit of total triiodothyronine. Materials and Methods: In this study, a total...

introduction: determination of thyrotropin, total and free thyroxine and triiodothyronine are widely used as diagnostic methods for thyroid function evaluation. there have been numerous reports of interferences in thyroid hormone immunoassays. herein, a prominent positive interference is reported for a radioimmunoassay kit of total triiodothyronine. materials and methods: in this study, a total...

BACKGROUND The ubiquitous use of dibutyl phthalate (DBP), one of the most widely used plasticizers, results in extensive exposure to humans and the environment. DBP and its major metabolite, monobutyl phthalate (MBP), may alter steroid biosynthesis and their exposure may lead to damage to male reproductive function. Low-doses of DBP/MBP may result in increased steroidogenesis in vitro and in vi...

We used co-cultures of porcine ovarian granulosa cells and mouse adrenocortical tumor cells (Y-1) to examine the kinetics of contact-dependent intercellular signal transfer and to assess the molecular mechanisms employed by this process. Exposure to follicle-stimulating hormone (FSH) caused cAMP-dependent protein kinase dissociation in granulosa cells and, with time, in Y-1 cells if, and only i...

British Journal of Cardiac NursingVol. 17, No. 1 Guest EditorialPostoperative cognitive dysfunction: what does it really mean?Tracey BowdenTracey BowdenCorrespondence to: Tracey Bowden; E-mail Address: [email protected]School Health Sciences, City, University London, UKSearch for more papers by this authorTracey BowdenPublished Online:1 Feb 2022https://doi.org/10.12968/bjca.2022.0005AboutSectio...