Animal models provide vital tools to explicate the pathogenesis of atherosclerosis. Accordingly, we established two atherosclerosis-prone mice models: (i) mice lacking the LDL (low-density lipoprotein) receptor (LDLR) and the ability to edit apo (apolipoprotein) B mRNA (Apobec1; designated LDb : LDLR-/- Apobec1-/-), and (ii) mice with the LDb background, who also overexpressed human apoB100 (de...

Arterial hypertension (AH) remains one of the most common diseases, cause of premature death and disability of patients. Heart is one of the main target organs in AH. The processes of cardiac remodeling in hypertension have been taken much attention recent years, as it is shown that left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular disease and sudden death [1-3...

The heat production during the ATP hydrolysis catalyzed by myosin subfragment 1 in 0.1 M KC1 containing 0.01 M MgClz and 0.02 M Tris/HCl (pH 7.8) at 23°C was followed using a microcalorimeter with an improved time resolution. The results indicate that: (a) the binding of ATP to Subfragment 1 is exothermic (AH = -90 kJ mol-‘, all the AH values are corrected for protonation heat of Tris). (b) The...

We investigated the role of mitochondria in the regulation of intracellular Ca2+ ([Ca2+]i) and excitability of myenteric neurons in guinea pig ileum, using microelectrodes and fura-2 [Ca2+]i measurements. In AH/Type-II neurons, action potentials evoke ryanodine-sensitive increases in [Ca2+]i that activate Ca2+-dependent K+ channels and slow afterhyperpolarizations (AH) lasting approximately 15 ...

BACKGROUND/AIM Adenoid hypertrophy (AH) is chronic enlargement of the adenoid tissue. The pathophysiology of the disease is unclear. We analyzed SCGB1D4 gene polymorphisms in order to determine the effect of the variants or their genetic combinations on AH. MATERIALS AND METHODS We genotyped the SCGB1D4 (IIS) gene in 167 participants (95 children with AH and 72 controls) by performing DNA seq...

Human plasma PAF-AH (platelet-activating factor-acetylhydrolase) is a Ca(2)+-independent phospholipase A2 of hematopoietic origin associated with LDL and HDL; it degrades PAF and oxidizes phospholipids. We show that human macrophages synthesize PAF-AH as a premedial Golgi precursor containing high mannose N-linked glycans. Secreted PAF-AH possesses a molecular mass of approximately 55 kDa and c...

AIM To describe our experience with alveolar hemorrhage (AH) in systemic lupus erythematosus (SLE). METHODS Review of medical records and pertinent medical literature using MEDLINE and reference lists from retrieved publications. PATIENTS Seven patients with SLE admitted with episodes of AH (n = 11). RESULTS Six patients were female, and one was male. Mean age at the time of AH was 31.1 y...

a4 + 1 a5 + .. . will see that a less wasteful notation, say [ a0 , a1 , a2 , . . . ] , is needed to represent it. Anyone attempting to compute the truncations [ a0 , a1 , . . . , ah ] = ph/qh will be delighted to notice that the definition [ a0 , a1 , . . . , ah ] = a0 + 1/[ a1 , . . . , ah ] immediately implies by induction on h that there is a correspondence ( a0 1 1 0 ) ( a1 1 1 0 ) · · · (...

Plasma platelet-activating factor acetylhydrolase (PAF-AH) hydrolyzes PAF and oxidized phospholipids and is associated with lipoproteins in the circulation. Endotoxin [lipopolysaccharide (LPS)], a potent inducer of the acute phase response (APR), produces marked changes in several proteins that play important roles in lipoprotein metabolism. We now demonstrate that LPS produces a 2.5- to 3-fold...