TUBERCULOID RELAPSE IN LEPROMATOUS LEPROSY Sir, Waters & Ridley ' recently reported 6 patients who had been lepromatous and who, after many years of chemotherapy and bacteriological negativity, were found on relapse to have upgraded to borderline-tuberculoid (BT) leprosy . In a related article,2 they reported the development of weakly posi tive lepromin reactions in some lepromatous patients tr...

One of the biggest challenges in treating leprosy is the control of reaction events. Patients with lepromatous leprosy may present reaction type II, or erythema nodosum leprosum, during treatment, and this reaction can remain in a recurrent form after being released from the hospital, requiring the use of thalidomide and/or prednisone for long periods of time, in turn increasing the risk of sid...

A 39-years-old male patient with previously treated borderline lepromatous (BL) leprosy, presented paresthesia and dysesthesia in the feet hands, associated fever, arthralgia, erythema nodosum during a Type-2 leprosy reaction (LR) episode. This evolved 3 days to flaccid tetraparesis areflexia, gait impairment, addition clinical signs of dysautonomia, such as tachycardia, tachydyspnea, cranial n...

The polar typ es of leprosy, tuberculoid and lepromatous, are eharacteri zed by two dif-ferent and well-defin ed form s of cellular resp0l1se (~fi). Tubereuloicl les ions consist of circumscribed granulom as made up of epithelioid cells which contain few leprosy bacilli. Lepromatous lesions, in contrast, are composed of diffuse aggregates of foamy macrophages ( Virehow cells ) laden with large ...

T n view of the fact that Isonicotinic Acid Hydrazid and Streptomycin have been shown to have an effect on the M. leprae, i t was considered advisable to test the combination of these two drugs in leprosy. A study was started , therefore, on a group of lepromatous cases in January, 1 954. I n March, 1 956, 4 more cases were added to th is series. In all 59 cases have been studied, of which 47 w...

BACKGROUND Patients with localized tuberculoid and generalized lepromatous leprosy show respectively Th1 and Th2 cytokine profile. Additionally, other patients in both types of leprosy also show a non discriminating Th0 cytokine profile with both interferon-γ and IL-4. The present study investigated the role of Th17 cells which appear to be a distinct subtype of Th subtypes in 19 tuberculoid an...

Leprosy (Hansen's disease) is a chronic granulomatous disease caused by Mycobacterium leprae (Hansen's bacillus). Oral manifestations occur in 20-60% of cases, usually in lepromatous leprosy, and are well documented. They may involve both the oral hard and soft tissues. Incidence of verrucous carcinoma/Ackerman's tumour developing in anogenital region and plantar surfaces of feet in lepromatous...

This paper presents cytomorphological features of the histoid variety of lepromatous leprosy. Fine needle aspiration of a lepromatous nodule showed cytological features consistent with those of histoid leprosy. Simultaneously, a biopsy of the nodule was also performed and the case confirmed as histoid leprosy. The advantages of the fine needle aspiration technique are that it is simple, quickly...

OBJECTIVES To assess the urinary nitric oxide metabolites in lepromatous patients in ENL (type 2 reactions) and to compare these metabolites after subsidence of reactions following antireactional therapy. Further to compare the levels in a group of lepromatous leprosy patients without reactions. DESIGN The initial urine samples were collected from lepromatous leprosy patients when they came w...

The immunology of leprosy is one of the most intriguing problems in disease processes ( 5. 10. 16. 19. 20. 21. 22). The forms in which leprosy may occur vary. The most important form, lepromatous leprosy, is characterized by a negative reaction to the leprous material injected into the skin. The opposite is true in the relatively more benign tuberculoid form of the disease. Between these two ar...