نتایج جستجو برای: hypoxia ischemia

تعداد نتایج: 133254  

2015
Anna-Luisa Thiepold Sebastian Luger Marlies Wagner Natalie Filmann Michael W. Ronellenfitsch Patrick N. Harter Anne K. Braczynski Stephan Dützmann Elke Hattingen Joachim P. Steinbach Christian Senft Johannes Rieger Oliver Bähr

BACKGROUND Hypoxia is a key driver for infiltrative growth in experimental gliomas. It has remained elusive whether tumor hypoxia in glioblastoma patients contributes to distant or diffuse recurrences. We therefore investigated the influence of perioperative cerebral ischemia on patterns of progression in glioblastoma patients. METHODS We retrospectively screened MRI scans of 245 patients wit...

Journal: :Bulletin of the National Research Centre 2022

Abstract Background Leptin exerts both protective and deleterious effects on the heart; first occurs under hypoxia- or ischemia-associated damage, second is a pro-hypertrophic factor cardiomyocytes. Therefore, leptin could represent link between obesity cardiovascular diseases. The study aimed to investigate effect of leptin—the same concentration that frequently measured in induces cardiac hyp...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Hiroaki Misonou Durga P Mohapatra Milena Menegola James S Trimmer

Ischemic stroke is often accompanied by neuronal hyperexcitability (i.e., seizures), which aggravates brain damage. Therefore, suppressing stroke-induced hyperexcitability and associated excitoxicity is a major focus of treatment for ischemic insults. Both ATP-dependent and Ca2+-activated K+ channels have been implicated in protective mechanisms to suppress ischemia-induced hyperexcitability. H...

Journal: :Stroke 1990
D J Mujsce J Towfighi D Stern R C Vannucci

To study the efficacy of mannitol in reducing cerebral edema and improving the ultimate neuropathologic outcome in perinatal cerebral hypoxia-ischemia, 67 7-day postnatal rats were subjected to unilateral common carotid artery ligation followed by exposure to 8% oxygen at 37 degrees C for 3 hours. Twenty-seven rat pups received a subcutaneous injection of 0.1 ml mannitol in a dosage of 4 mg/kg ...

Journal: :Arteriosclerosis, Thrombosis, and Vascular Biology 2010

Journal: :Investigative ophthalmology & visual science 2016
Suna Jung Aaron Johnstone Zehra Khoja Emmanouil Rampakakis Pierre Lachapelle Pia Wintermark

PURPOSE The purpose of this study was to investigate the effects of sildenafil on retinal injury following neonatal hypoxia-ischemia (HI) at term-equivalent age in rat pups. METHODS Hypoxia-ischemia was induced in male Long-Evans rat pups at postnatal day 10 (P10) by a left common carotid ligation followed by a 2-hour exposure to 8% oxygen. Sham-operated rats served as the control group. Both...

2015
Hossein Ali Ghaffaripour Mehdi Jalali Mohammad Reza Nikravesh Masoumeh Seghatoleslam Javad Sanchooli

BACKGROUND Brain hypoxia-ischemia is a human neonatal injury that is considered a candidate for stem cell therapy. METHODS The possible therapeutic potential of human umbilical cord blood (HUCB) stem cells was evaluated in 14-day-old rats subjected to the right common carotid occlusion, a model of neonatal brain hypoxia-ischemia. Seven days after hypoxia-ischemia, rats received either saline ...

2017
Jeannette Vasquez-Vivar Zhongjie Shi Kehuan Luo Karthikeyan Thirugnanam Sidhartha Tan

Antenatal brain hypoxia-ischemia, which occurs in cerebral palsy, is considered a significant cause of motor impairments in children. The mechanisms by which antenatal hypoxia-ischemia causes brain injury and motor deficits still need to be elucidated. Tetrahydrobiopterin is an important enzyme cofactor that is necessary to produce neurotransmitters and to maintain the redox status of the brain...

2018
Floyd Gilles Pierre Gressens Olaf Dammann Alan Leviton

Brain injury in preterm newborn infants is often attributed to hypoxia-ischemia even when neither hypoxia nor ischemia is documented, and many causative speculations are based on the same assumption. We review human and animal study contributions with their strengths and limitations, and conclude that - despite all the work done in human fetal neuropathology and developmental models in animals ...

Journal: :Stroke 2007
Matthew Derrick Alexander Drobyshevsky Xinhai Ji Sidhartha Tan

Disorders of the maternal-placental-fetal unit often results in fetal brain injury, which in turn results in one of the highest burdens of disease, because of the lifelong consequences and cost to society. Investigating hypoxia-ischemia in the perinatal period requires the factoring of timing of the insult, determination of end-points, taking into account the innate development, plasticity, and...

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