The purpose of this study was to investigate the potential responses of the cardiovascular system and regional blood flow to hypoxic hypoxia (BB) and to carbon monoxide (CO)-induced hypoxia (COH). Ten anesthetized cats were studied under two nonnoxic (control: CONT) and two hypoxic conditions. Four types of radioactive micro spheres were used to measure regional blood flow during CONT an...

It is well known that the metabolic factors play an important role in the regulation of angiogenesis. Increased metabolic activity leads to decreased oxygen levels and causes tissue hypoxia. Hypoxia starts different signals to stimulate angiogenesis and promotes oxygen delivery to tissues. It has been suggested that released adenosine from hypoxic tissues plays a vital role in angiogenesis. ...

Background: The mevalonate pathway generates endogenous cholesterol and intermediates including geranylgeranyl pyrophosphate (GGPP). By reducing GGPP production, statins exert pleiotropic or cholesterol-independent effects. potential regulation of homeostasis through dietary intake the interaction with concomitant statin therapy is unknown. Methods: We developed a sensitive high-pressure liquid...

The aim of the present study was to determine mRNA expression profiles TRAIL-mediated cell death related genes hypoxia-tolerant rodent Nannospalax nehringi under hypoxia. nucleotide and amino acid sequences these were identified. Captured randomly divided into normoxia hypoxia groups. group exposed a 7% O2 + 93% N2 gas mixture for 52 h, while animals in housed normoxic conditions. Total RNAs is...

background: nepeta dschuparensis bornm (np) is used as a medicinal herb in iran. in traditional medicine, this herb is extensively employed for curing ailments such as cardiovascular diseases. np has antioxidant and anti-inflammatory properties. this project examined the effects of the np extract on cyclooxygenase-2 (cox-2) and interleukin-1β (il-1β) protein levels and its efficacy in neuroprot...

Hypoxia, a deficiency in the levels of oxygen, is common feature most solid tumors and induces many characteristics cancer. Hypoxia associated with metastases strong resistance to radio- chemotherapy, can decrease accuracy cancer prognosis. Non-invasive imaging methods such as positron emission tomography (PET) single-photon computed (SPECT) using hypoxia-targeting radiopharmaceuticals have bee...

Abstract Background Hypoxia-mediated radioresistance is the main obstacle to successful treatment of glioblastoma (GBM). Enhancing hypoxic radiosensitivity and alleviating tumor hypoxia are both effective means improve therapeutic efficacy, combination two highly desirable meaningful. Results Herein, we construct a low-dose pleiotropic radiosensitive nanoformulation consisting high-Z atomic nan...

The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely vulnerable hypoxia, whether at high altitude or in clinical settings anemia pulmonary disease. Hypoxia is pivotal pathogeneses myriad neurological disorders, including Alzheimer’s, Parkinson’s and other age-related neurodegenerative diseases. Conversely, reduced environmental oxygen, e.g. sojourns residing...

rhododendron dauricum l. is an ancient chinese traditional herb. the pharmacological effects of r. dauricum extract have been shown in chronic tracheitis. the aim of this study was to investigate the cardiovascular effects of rhododendron dauricum l. flavonoids (rf) on rats and its mechanisms. this study was performed in isolated vascular rings and a rat model of myocardial infarction and isola...