abstract introduction major ß thalassemia represents a group of recessively inherited hemoglobin disorder, which is characterized by reduced synthesis of globins chains. frequent blood transfusions can lead to iron overload, which may result in several endocrine complication especially in the absence of adequate chelating therapy. the objective of this study were to determine the prevalence of ...

hypothyroidism is usually associated with delayed pubertal development but in rare occasions precocious puberty may ensue which is seen in cases of prolonged and untreated hypothyroidism. this is also called the van wyk grumbach syndrome. here we present 4 cases of precocious puberty due to hypothyroidism.

introduction: hypothyroidism is diagnosed by elevated thyroid stimulating hormone (tsh) and normal or decreased serum levels of t4 or t3, and is associated with a wide range of m etabolic abnormalities, including anemia. this clinical study aimed to assess the improvement of anemia in patients with primary hypothyroidism following administration of levothyroxine in iranian population. materials...

background: fanconi anemia (fa) is a rare, autosomal recessive (ar) and multifactorial disorder. a high prevalence of fa observed in iran is perhaps due to the high rate of consanguineous marriages. this study investigates the extent of short stature in patients with fa, the frequency of hypothyroidism in fa and the correlation between height and hypothyroidism.   methods: eighteen patients wit...

Objective: To determine the frequency of hypothyroidism in patients with pulmonary hypertension. Study Design: Observational Cross-sectional study. Setting: Department Medicine, Sandeman Provincial Hospital, Bolan University Medical & Health Sciences Quetta Pakistan. Period: March 2020 to 2021. Material Methods: Pulmonary Hypertension was defined as mPASP >25 mm Hg at rest on transthorac...

OBJECTIVE Skeletal development, linear growth, cartilage biology and bone turnover are highly dependent on the activity of thyroid hormones. Thyroid dysfunction affects the skeleton, and autoimmune thyroid disease, manifesting as a chronic inflammatory condition, may be an important contributing factor to impaired bone quality in these patients. MATERIALS AND METHODS Measurement of TSH, FT4, ...

congenital hypothyroidism is a condition of thyroid hormone deficiency. approximately 1 in 4000 newborn infants has a deficiency of thyroid function. the aim of this study is determination of the prevalence of permanent and transient congenital hypothyroidism (ch) in yazd, iran.from may 2006 to june 2008, 35377 newborns were screened by measuring serum tsh obtained by heel prick. the neonates w...

Background & Aims: Since at early pregnancy (<20 week) fetal thyroid gland is undeveloped, normal development of the Fetal brain is highly dependent on maternal thyroid hormones. There are excessive adverse perinatal outcomes associated with overt and subclinical hypothyroidism such as increase of Abortion, preeclampsia, placenta Abruption, LBW, preterm labor, impaired fetal neuropsychological ...

The main purpose of our retrospective study was to evaluate the medical care of the patients with subclinical hypothyroidism (sHT) and to investigate the rationale for administering L-thyroxine (LT-4) to young sHT patients. Patients and Methods. Based on a retrospective review of the charts of 261 patients referred to the Endocrinology Outpatient Clinic between 2009 and 2014 with suspicion of s...