Cushing's disease is a condition in which hypercortisolism develops due to excessive hypophyseal adrenocorticotropic hormone production. It is rare in childhood. In this paper, we report the case of a 10-year-old male patient with hypophyseal microadenoma-related Cushing's disease who presented with obesity and was found to show poor height growth at follow-up. The diagnosis was confirmed with ...

Since the classical experiments of Houssay and Biasotti (1), Evans, Meyer, Simpson and Reichert (2), Young (3), and Long and Lukens (4), the diabetogenic potential of pituitary hormones has been amply documented (5). However, the metabolism of glucose by the pituitary has received but little examination (6-9), and the authors have been unable to find any published studies of the hormonal determ...

The effects of estradiol benzoate (EB) injection on sexual development and the pituitary gland were studied in 240 immature rats after 16 weeks of treatment. Treatment resulted in eunuchoid dwarfing. Males showed enlargement of the pituitary after 4 months, while in females it remained normal. After continued treatment for 8 months, enormous hypophyseal tumors were observed in 29 of 35 rats ...