نتایج جستجو برای: hypophosphatasia

تعداد نتایج: 591  

Journal: :European Journal of Human Genetics 2010

2009

Osteomalacia is a condition characterised by failure of bone mineralisation. While abnormalities of vitamin D supply, metabolism or action are the most common and well-known causes, chronic phosphate deficiency, due to either insufficient input (intake or absorption) or renal losses are also important causes of rickets or osteomalacia.1 Hypophosphataemia also commonly co-exists with vitamin D d...

Journal: :Annals of the Rheumatic Diseases 2023

Background Hypophosphatasia(HPP), a rare, inherited metabolic disease featuring low serum alkaline phosphatase (ALP) activity due to ALPL (encoding tissue non-specific phosphatase) gene mutation [1,2] . A wide-ranging clinical spectrum is often seen defective mineralisation affecting teeth, bones, joints and muscles [1] This has prevalence of 1/6370 in Europe misdiagnosed underdiagnosed with di...

Journal: :Nihon Naika Gakkai Zasshi 1988

Journal: :American Journal of Perinatology Reports 2020

Journal: :Annals of the Rheumatic Diseases 1989

Journal: :Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003
Michael P Whyte Joanne Kurtzberg William H McAlister Steven Mumm Michelle N Podgornik Stephen P Coburn Lawrence M Ryan Cindy R Miller Gary S Gottesman Alan K Smith Judy Douville Barbara Waters-Pick R Douglas Armstrong Paul L Martin

An 8-month-old girl who seemed certain to die from the infantile form of hypophosphatasia, an inborn error of metabolism characterized by deficient activity of the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP), underwent the first trial of bone marrow cell transplantation for this heritable type of rickets. After cytoreduction, she was given T-cell-depleted, haplo-identical marr...

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