Altered state theories of hypnosis posit that a qualitatively distinct state of mental processing, which emerges in those with high hypnotic susceptibility following a hypnotic induction, enables the generation of anomalous experiences in response to specific hypnotic suggestions. If so then such a state should be observable as a discrete pattern of changes to functional connectivity (shared in...

Although hypnosis is now less popular as an interviewing technique in forensic investigations than it used to be, recent evidence suggests that some of the components of hypnotic interviewing might still be useful in the development of brief memory facilitation procedures. Two experiments are described which continue this componential approach to hypnotic interviewing. In the fi rst experiment,...

BACKGROUND Ketamine is a commonly used anesthetic, but the mechanistic basis for its clinically relevant actions remains to be determined. The authors previously showed that HCN1 channels are inhibited by ketamine and demonstrated that global HCN1 knockout mice are twofold less sensitive to hypnotic actions of ketamine. Although that work identified HCN1 channels as a viable molecular target fo...

Although agarwood has been used as a tranquilizer in Asian countries for hundreds of years, the underlying pharmacological basis is still unclear. This study investigated the sedative-hypnotic effect of agarwood essential oil (AEO) using locomotor activity and pentobarbital-induced sleeping assays in mice. Single (1-day) and multiple (7- and 14-days) administrations of 60 mg/kg AEO generated si...

Clinical trials with cannabidiol (CBD) in healthy volunteers, isomniacs, and epileptic patients conducted in the authors' laboratory from 1972 up to the present are reviewed. Acute doses of cannabidiol ranging from 10 to 600 mg and chronic administration of 10 mg for 20 days or 3 mg/kg/day for 30 days did not induce psychologic or physical symptoms suggestive of psychotropic or toxic effects; h...

background: coriandrum sativum l. has been recommended for relief of insomnia in iranian traditional medicine. however, no pharmacological studies have yet evaluated its sedative effects. the aim of this study was to determine if extracts and essential oil of coriander seeds have sedative-hypnotic activity.   methods: the aqueous or hydro-alcoholic extracts or essential oil of coriander seeds (...

EEG was recorded monopolarly at frontal (F3, F4), central (C3, C4) and occipital (O1, O2) derivations during A-B-A conditions of waking rest, hypnosis (rest, arm immobilization, mosquito hallucination, hypnotic dream), and waking rest. Stringently screened on several measures of hypnotic susceptibility, 12 very low hypnotizable and 12 very highly hypnotizable, right-handed undergraduate, subjec...

One of the most robust findings in the literature on hypnotic suggestibility is that there are large individual differences in the extent to which people respond to imaginative suggestions. Although approximately 15-20 percent of people respond to very few suggestions, a comparable percentage of individuals respond to an array of suggestions for changes in sensation, perception, cognition, and ...

Evidence indicates that sensitivity to ethanol is a good predictor of the development of alcoholism. Thus, identification of neuronal processes that regulate ethanol sensitivity has been the subject of much recent research. The present studies were designed to further test the hypothesis that neurotensinergic processes mediate, in part, hypnotic sensitivity to ethanol. Single doses of haloperid...