Masseter muscle hypertrophy can be defined as a rare, asymptomatic, atypical amplification of the masseter muscle, moreover in unilateral or bilateral pattern which is manifested form an intensified mass. The treatment may not importance and just removal/correction etiological trigger factor responsible for it. Appropriate diagnosis management disease process should part teaching curriculum tau...

In human hypertrophic cardiomyopathy and hypertension associated ventricular hypertrophy, chronic use of calcium channel blockers results in a significant regression of hypertrophy. The main objective of this study was to test the hypothesis that modulation of calcium influx through the voltage-sensitive L-type Ca2+ channel directly affects myocardial hypertrophy. Agents that modified calcium i...

This study was designed to investigate the expression of short-chain acyl-CoA dehydrogenase (SCAD), a key enzyme of fatty acid β-oxidation, during rat heart development and the difference of SCAD between pathological and physiological cardiac hypertrophy. The expression of SCAD was lowest in the foetal and neonatal heart, which had time-dependent increase during normal heart development. In con...

Identifying the key factor mediating pathological cardiac hypertrophy is critically important for developing the strategy to protect against heart failure. Bone morphogenetic protein-4 (BMP4) is a mechanosensitive and proinflammatory gene. In this study, we investigated the role of BMP4 in cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy. The in vi...

Background Urinary albumin excretion has been associated to cardiovascular events and increased mortality in hypertensive patients. There is limited information among Nepalese patients about the implications of microalbuminuria (MA) setting hypertension potential morbidity.
 Objective To investigate prevalence with essential its connection left ventricular hypertrophy (LVH) carotid artery ...

Objectives: To determine the pattern of histological findings in prostatic chips obtained from cases enlarged prostate gland and to correlate with PSA levels. Materials Methods: It was a cross sectional descriptive study conducted Northwest General Hospital , Peshawar 1st January 2018 23rd December 2021. A total 500 male features prostate, frequency, urgency dribbling mean age 52 ± 12.3 years (...

Objective(s): Gestational diabetes increases the risk of congenital heart disease in the offspring, but the molecular mechanism underlying this process remains unclear. Therefore, the current study was conducted to assess the effects of induced gestational diabetes on expression of some involved genes in cardiac hypertrophy in the offspring of diabetic rats.Materials and Methods: Diabetes was i...

Introduction: The aim of the study was to investigate the structural and hemodynamic changes as well as cardiac transcriptional profile of the key regulatory proteins, sirtuins family (SIRT1-7), in adaptive and mal-adaptive phases of left ventricular hypertrophy (LVH). Methods: LVH was induced in male Wistar rats (190±20g) by abdominal aortic banding. The third and sixteenth weeks post-surgery ...