Delayed-type hypersensitivity reaction or type IV allergic reaction can cause different oral manifestations. They can be localized or diffusely visible on oral mucosa and usually appear 24-72 hours after antigen input. The antigens that cause this type of reaction are mostly external, such as contact allergens (particularly metals) and drugs. It has been shown that the most common oral manifest...

BACKGROUND Oxaliplatin is a platinum compound used in the treatment of gastrointestinal malignancies, including colorectal cancer. The incidence of hypersensitivity reaction in patients receiving oxaliplatin is approximately 15%, with severe reaction (grade 3 and 4) occurring in 2% of patients. CASE PRESENTATION We report two patients with metastatic colorectal cancer who developed de novo hy...

PURPOSE To determine correlation between metal hypersensitivity and long-term foot and ankle function and pain after internal fixation using stainless steel implants. METHODS 60 men and 46 women (mean age, 47 years) who underwent internal fixation for ankle fractures completed a questionnaire 13 to 38 (mean, 26) months after surgery to assess their existing medical condition, history of metal...

Delayed hypersensitivity reaction in mice was commonly enhanced with various anti-cancer agents administered as single or intermittent high doses but not consecutive divided doses. The effect of anti-cancer agents on the delayed hypersensitivity reaction was thought to be due to elimination of suppressor T cell activity.