The hypothalamus is critical for feeding and body weight regulation. Prevailing studies focus on hypothalamic neurons that are defined by selectively expressing transcription factors or neuropeptides including those expressing proopiomelanocortin (POMC) and agouti-related peptides (AgRP). The Cre expression driven by the pancreas-duodenum homeobox 1 promoter is abundant in several hypothalamic ...

Prader Willi (PWS) is the most common and rare genetic cause of obesity. Airway problems associated with obesity hypotonia, increased risk aspiration due to gastrointestinal (GI) motility hyperphagia, obstructive sleep apnea syndrome (OSAS), difficult airway management, postoperative respiratory failure narrow are factors that complicate anesthesia management. It should be noted there many anat...

Artificial food supplementation of wildlife is an increasing practice for species conservation, as well hunting and viewing tourism. Yet, our understanding the implications supplementary feeding still very limited. Concerns have been raised over potential negative impact artificial feeding, but effects this on animal movements rhythms activity are just beginning to be investigated. Here, with a...

Hypothalamic systems which regulate appetite may be permanently modified during early development. We have previously reported hyperphagia and increased adiposity in the adult offspring of rodents fed an obesogenic diet prior to and throughout pregnancy and lactation. We now report that offspring of obese (OffOb) rats display an amplified and prolonged neonatal leptin surge, which is accompanie...