To investigate the effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rats, female Wistar rats were fed a high-cholesterol diet (HCD) for 28 d to generate hyperlipidemic models. Hyperlipidemic rats were assigned to four groups, which were individually treated with three different dosages of K. marxianus M3+HCD or physiological saline+HC...

Porphyromonas gingivalis has been shown to accelerate atherosclerotic lesion development in hyperlipidemic animals. We assessed the potential of a nasal vaccine against P. gingivalis infection for the prevention of atherosclerosis. Apolipoprotein E-deficient spontaneously hyperlipidemic (Apoe(shl)) mice were nasally immunized with the 40-kDa outer membrane protein (OMP) of P. gingivalis plus ch...

We investigated the effects of purified eicosapentaenoic acid (EPA) on vascular endothelial function and free fatty acid composition in Japanese hyperlipidemic subjects. In subjects with hyperlipidemia (total cholesterol ≥220 mg/dL and/or triglycerides ≥150 mg/dL), lipid profile and forearm blood flow (FBF) during reactive hyperemia were determined before and 3 months after supplementation with...

Acyl-CoA:cholesterol acyltransferase (ACAT) catalyzes cholesterol esterification in mammalian cells. Two isoforms of ACAT have been reported to date (ACAT-1 and ACAT-2). ACAT-1 protein is ubiquitously expressed in tissues, including macrophages, hepatocytes, adrenal glands, and intestines. In contrast, ACAT-2 is expressed mainly in the intestine in humans. However, the roles of ACAT-1 and ACAT-...

BACKGROUND Pharmaceutical research of hyperlipidemia has been commonly pursued using traditional approaches. However, unbiased metabonomics attempts to explore the metabolic signature of hyperlipidemia in a high-throughput manner to understand pathophysiology of the disease process. METHODOLOGY/PRINCIPAL FINDINGS As a new way, we performed (1)H NMR-based metabonomics to evaluate the beneficia...

Background: Choerospondias axillaris CA, known as lapsi, is a plant with constituents having therapeutic properties. All parts including stem, bark, root, leaves, and fruit have medicinal virtues had role in Ethno-medicine since ancient times.
 Objective: The present study was designed to investigate the antihyperlipidemic activity of dried powder fruits Wistar albino rats.
 Methods: ...

Familial combined hyperlipidemia (FCH) is the most common familial hyperlipidemia with a high risk for early atherosclerosis. The aim of this study was to compare levels of soluble intercellular cell adhesion molecule 1 (s-ICAM-1) and soluble vascular cell adhesion molecule 1 (s-VCAM-1) in asymptomatic members of FCH families with healthy controls and to determine the relation between s-ICAM-1,...

The aim of this study was to evaluate the anti-hyperlipidemic effect methanol Mangifera indica seed kernel extract on hyperlipidemic Wistar rats. Mango kernels were dried at room temperature before being ground into fine powder. 500 g mango powder soaked in mL 98 % and shaken intermittently for 72 h, after which concentrated. Twenty five adult male wistar rats divided groups each. Group I: admi...

Purpose: To evaluate the antioxidant and antihyperlipidemic activities of the methanol extract of aerial part of Crassocephalum crepidioides (Asteraceae) Benth. S. Moore. Methods: The methanol extract of Crassocephalum crepidioides was prepared by organic solvent extraction (Maceration) and assessed for in vitro antioxidant activity using various methods, namely, 2,2-diphenyl-1-picrylhydrazyl (...

Citrus peels, citrus juices factories waste by-products are valuable functional food. This investigation evaluated activity citrus peels powders fortified biscuits antihyperlipidemic in induced hyperlipidemic rats. 10% fortified biscuits (FB) with peels powders of four citrus groups, namely: Hyperlipidemic basal diet (HLD) + 10% (FB) with Baladi orange peels powder (PP); HLD + 10% FB with 10% A...