The combination of arterial hypertension and metabolic syndrome leads to an increased risk development cardiovascular complications. Early detection asymptomatic target organ damage determine additional is important, because pressure-dependent subclinical several organs reflects progression along the disease continuum. SCORE scale based on data from a number recent European multicenter studies ...

Chronic activation of the sympathetic nervous system may be a pathogenetic mechanism by which hyperinsulinemia induces cardiovascular damage in insulin-resistant NIDDM patients. The influence of physiological hyperinsulinemia (approximately 700 pmol/l) on basal and stimulated sympathetic outflow was studied in 12 lean normotensive subjects with well-controlled NIDDM without complications and in...

We investigated the time course of insulin action in conscious rats exposed to constant physiological hyperinsulinemia (∼100 mU/l) while maintaining euglycemia (∼100 mg/dl) for 0, 0.5, 2, 4, 8, or 12 h. [3-3H]glucose was infused to quantitate whole body glucose disposal (rate of disappearance, Rd), glycolysis (generation of3H2O in plasma), hepatic glucose production (HGP), and skeletal muscle a...

and Hyperinsulinemia To the Editor: QTc dispersion is an important predictor of cardiac mortality. In the Rotterdam Study,1 persons in the highest tertile (.60 ms) relative to the lowest tertile (,39 ms) of QTc dispersion had a 2-fold risk of cardiac death. The Rotterdam Study also confirms that QTc dispersion is larger in diabetic than in nondiabetic persons. QTc duration and QTc dispersion ar...

Congenital hyperinsulinemic hypoglycemia (CHI) is the common cause of severe hypoglycemia in infancy. Profound hypoglycemia requires appropriate diagnosis and aggressive treatment to prevent severe and irreversible brain damage. Here we report 21 Japanese hypoglycemia cases with severe hyperinsulinemia. We report 16 CHI cases, 2 HIHA cases, 1 GSD1b case and 2 PSS cases. 12 cases of CHI had seve...