OBJECTIVES Hypericum perforatum L. is a medicinal plant containing many polyphenolic compounds, ‎including flavonoids and phenolic acids with antidepressant and anti-inflammatory properties. ‎This study was investigated the effects of Hypericum perforatum extract (HPE) on immunity, ‎body weight (BW), and spleen index (SI) in rats.‎ MATERIALS AND METHODS A total of 24 Wistar male rats were ran...

Oliver St John Gogarty (1878-1957) was a celebrated Irish doctor and poet. A 'Renaissance' figure, he was renowned as a surgeon, poet, memoirist, senator, athlete and wit. His years as a medical student, although not crowned by academic success, were remarkable for many other achievements. A study of Gogarty's University career provides a number of lessons in the art of being a medical student....

In the genus Hypericum, cryoconservation offers a strategy for maintenance of remarkable biodiversity, emerging from large inter- and intra-specific variability in morphological and phytochemical characteristics. Long-term cryostorage thus represents a proper tool for preservation of genetic resources of endangered and threatened Hypericum species or new somaclonal variants with unique properti...

St. John's Wort (Hypericum perforatum), a perennial flowering plant, has been used medicinally for thousands of years, and has most recently been identified as an effective treatment for mild to moderate depression. Clinical studies on the use of this plant for depression have utilized liquid tinctures and standardized solid extracts (0.3% hypericin--300 mg three times a day). Severe depression...

Introduction: Hypericum perforatum L was coded in medicinal plants research center of Shaheed Beheshti university and using decoction method was extracted. There are many reports concerning the antidepressant effects of Hypericum perforatum L. (HP), but there are few studies indicating its antinociceptive effects of Hypericum specially Hypericum perforatum L. Materials & Methods: In this expe...

The process extraction of hypericin from the aerial parts Hypericum scabrum and perforatum was studied. On basis results research, following conditions were established: extractant – 80% ethanol, particle size raw material no more than 8 mm temperature 20–40 °C. By method mathematical planning experiment according to Box-Wilson, determined, which ensure with a yield 95%. Proposed five-fold H. n...

The study shows the influence of the origin of plant material and biological source on the in vitro antioxidant (neutralization of DPPH and OH radical, nitric oxide, and inhibition of lipid peroxidation) and anticholinesterase activity of chemically characterized and quantified ethanol extracts of ten St. John's wort samples. The investigated samples were: five Hypericum perforatum species repr...

Hypericum perforatum is a medicinal plant which has been known in traditional medicine as an antiinflammatory and healing agent. Nowadays the use of Hypericum extracts is concerned mainly with antidepressive applications. In the present work, HPLC – RPC18 column chromatography with photodiode array detection was applied for the determination of the derivatives of cinnamic and benzoic acid (e.g....