Anaplastic large cell lymphoma (ALCL) expressing the anaplastic kinase (ALK) (ALK + ALCL) is a rare type of which comprises 10-15% all non-Hodgkin lymphomas in children and 2–3% young adults. Relapsed/refractory disease occurs even more rarely (25–40% cases). There as yet no standard treatment for relapsed/refractory ALK ALCL. Patients with ALCL usually present at advanced stages extranodal inv...

Concurrent chemoradiotherapy (CCRT) is an important treatment modality for malignancies.1, 2 Neutropenia the most common hematological toxicity of CCRT and can often lead to febrile neutropenia (FN), toxic shock, even death, which not only seriously impact clinical survival cancer patients, but also increase their medical expenses.3-5 Numerous national international organizations have published...