Mutations in the REM1 gene of Saccharomyces cerevisiae confer a semidominant hyper-recombination and hypermutable phenotype upon mitotic cells ( GOLIN and ESPOSITO 1977). These effects have not been observed in meiosis. We have examined the interactions of rem1 mutations with rad6-1, rad50 -1, rad52-1 or spo11 -1 mutations in order to understand the basis of the rem1 hyper-rec phenotype. The ra...

During this week’s practical we will focus on understanding and comparing the performance of the different classification methods seen in class, namely SVM and its variants (C-SVM and ν-SVM, RVM) and an instance of a Boosting method, specifically AdaBoost. In non-linear classification methods such as SVM/RVM, we seek to find the optimal hyper-parameters (C: penalty, ν: bounds, σ: kernel width f...

Traumatic brain injury (TBI) from a blow to the head is often associated with complex patterns of brain abnormalities that accompany deficits in cognitive and motor function. Previously we reported that a long-term consequence of TBI, induced with a closed-head injury method modelling human car and sporting accidents, is neuronal hyper-excitation in the rat sensory barrel cortex that receives t...

Background Longitudinal associations between leukocyte subtype counts and LDL cholesterol have not been reported. Methods and Results This is a retrospective observational study in a health screening population. Spearman's correlation coefficients were calculated between leukocyte subtype counts and LDL cholesterol levels at baseline and after four years. Using Cox regression models, hazard r...

Fragile X syndrome (FXS) is characterized by sensory hyper-sensitivity, and animal models suggest that neuronal hyper-excitability contributes to this phenotype. To understand how sensory dysfunction develops in FXS, we used the rat model (FMR-KO) to quantify the maturation of cortical visual responses from the onset of responsiveness prior to eye-opening, through age equivalents of human juven...

In this paper, hyper-Fibonacci and hyper-Lucas polynomials are defined some of their algebraic combinatorial properties such as the recurrence relations, summation formulas, generating functions presented. addition, relationships between given.

In this paper, we introduce the notion of hyper pseudo B C K - algebras, which is a generalization of pseudo BCK -algebras and hyper BCK -algebras and we investigates some related properties. In follow, we de ne some kinds of hyper pseudo BCK -ideals of a hyper pseudo BCK - algebra and we find the relations among them. Finally, we characterize the hyper pseudo BCK -ideals of type 4 generated by...

OBJECTIVE To validate fasting indices of insulin sensitivity and secretion in a diverse pediatric population against gold standard estimates from euglycemic and hyperglycemic clamps. RESEARCH DESIGN AND METHODS A total of 31 children (mean BMI 25.1 +/- 4.9 kg/m(2), mean age 8.7 +/- 1.4 years, 15 girls and 16 boys, 12 black and 19 white) underwent euglycemic and hyperglycemic clamps 2-6 weeks ...