In this study, an injectable bone substitute (IBS) consisting of citric acid, chitosan, and hydroxyl propyl methyl cellulose (HPMC) as the liquid phase and tetra calcium phosphate (TTCP), dicalcium phosphate dihydrate (DCPD) and calcium sulfate dehydrate (CSD, CaSO4 x 2H2O) powders as the solid phase, were fabricated. Two groups were classified based on the percent of citric acid in the liquid ...

The present investigation reports the design and evaluation of six-hour extended release film-coated matrix tablets of cephalexin using different grades of hydrophilic polymer hydroxypropylmethylcellulose (HPMC) employing direct compression method. The preformulation studies performed included the physical compatibility studies, Differential Scanning Calorimetry analysis, drug characterization ...

Paliperidone is a well known dopamine antagonist of the atypical antipsychotic class. In the present study Paliperidone was formulated as ER release tablets using natural and synthetic polymers separately or in combination. The aim of ER release formulation is to reduce the frequency of dosing. Tablets are prepared by direct compression method. The optimized formulations contain Paliperidone as...

Thymol, an important and advantageous component of many essential oils, has been applied as an antimicrobial agent in animals. To increase the duration of action of this compound in ruminants, it was decided here to prepare a controlled release carrier for thymol. Hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose (EC) were used as the matrix polymer here. Mixtures of thymol with eight ...

The objective of this study was to develop a transdermal therapeutic system for meloxicam (MX) using various polymers like hydroxy propyl methyl cellulose (HPMC), ethyl cellulose (EC) and polyvinyl pyrrolidone (PVP) and plasticisers by solvent casting technique. The prepared patches were evaluated for physicochemical properties, in vitro release, in vitro skin permeation and in vivo release. Th...

Investigation on natural sources from plants, animals, and microorganisms that produce gums mucilages goes increasing day by to check their pharmaceutical applications. Different have been studied for effects but the use of date palm (Phoenix dactylifera L.) mucilage as a excipient is still under cover. The aim this study was therefore evaluate compare flow property binding ability crude, purif...

In the present study, several combinations of different grades of hydroxy propyl methyl cellulose (HPMC) such as HPMC-K4M, HPMC-K15M, HPMC-K100M as hydrophilic polymers and hydrophobic polymer like ethyl cellulose(EC) are used to prepare the matrix tablets that resulted in desired and controlled drug release profile. Hydrophobic polymers provide several advantages including good stability at va...

The objective was to describe and recommend the most effective combination of Natural-Based Product (NBP) mucoadhesive for Recurrent Aphthous Stomatitis (RAS) treatment. This systematic review writing based on PRISMA guidelines. articles published in last 10 y were selected using PubMed Google Scholar database carried out during May 2021. keywords were: natural-based product, mucoadhesive, Stom...

This paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). Tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

Article history: Received on: 15/12/2012 Revised on: 24/02/2013 Accepted on: 11/03/2013 Available online: 30/03/2013 Verapamil Hydrochloride is a calcium channel blocking anti-anginal agent. Extensive first pass metabolism, low bioavailability (~20%) and short biological half life (4.8 hrs) altogether makes it an ideal candidate for transdermal drug delivery. The objectives of this study were t...