Synthetic biopolymers are commonly used for the repair and regeneration of damaged tissues. Specifically targeting bone, the composite approach of utilizing inorganic components is considered promising in terms of improving mechanical and biological properties. We developed gelatin-apatite co-precipitates which mimic the native bone matrix composition within poly(lactide-co-caprolactone) (PLCL)...

Apatite-polymer composites mimicking specific structure of natural bone are promised as bone substitutes with moderate flexibility able to be fabricated into desired shapes as well as bone-bonding bioactivity. In order to precipitate the apatite on polymer surfaces, aqueous processing using solution supersaturated to the apatite has been attracting as much attention. Polyglutamic acid (PGA) is ...

Aim: Calcium silicate cements are widely used in endodontics. Novel fast-setting calcium silicate cement with fluoride (Protooth) has been developed for potential applications in teeth crowns including cavity lining and cementation. Objective: To evaluate the surface apatite-forming ability of Protooth compositions as a function of fluoride content and immersion time in phosphate-buffered salin...

The ability of bile salts to inhibit the precipitation of either calcium hydroxyapatite or its precursor, amorphous calcium phosphate, by reducing Ca2+ activity or poisoning nascent crystals was determined. When apatite precipitated rapidly (1-4 h), glycocholate and taurine-conjugated bile salts (up to 100 mM) had little effect on apatite formation, but prevented amorphous calcium phosphate pre...

This article is a review of the published literature on apatite glass-ceramics (GCs). Topics covered include crystallization mechanisms of the various families of apatite GCs and an update on research and development on apatite GCs for applications in orthopedics, dentistry, optoelectronics, and nuclear waste management. Most apatite GCs crystallize through a homogenous nucleation and crystalli...

Rat liver chromatin was titrated by poly-D-lysine of mol.wt. 140,000. Approximately 32% of the phosphate groups of the chromatin were found to react with the polycation. By submitting the chromatin-poly-D-lysine complex to pronase and DNase I digestion and by further submitting the obtained DNA-lysine complex to hydroxy-apatite-chromatography, “free” DNA was isolated. The mean S-value of this D...

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

different samples have been prepared from different products in chadormalu iron ore concentrator plant: low intensity magnetite separators concentrate (magnetite concentrate), reverse flotation tail (final hematite concentrate), flotation concentrate (apatite concentrate), final tail (l.i.m.s. tail + reverse flotation concentrate+ apatite flotation tail). the samples were used for rare earth el...