The hydroxycarboxylic acid family of receptors (ENSFM00500000271913, nomenclature as agreed by the NC-IUPHAR Subcommittee on Hydroxycarboxylic [36, 12]) respond to organic acids, including endogenous hydroxy carboxylic acids 3-hydroxy butyric and L-lactic acid, well lipid lowering agents nicotinic (niacin), acipimox acifran [53, 60, 65]. These were provisionally described receptors, although sh...

We report an efficient method to prepare polysubstituted 3-hydroxypyridines from amino acids, propargyl alcohols, and arylboronic acids. The process involves Pd(0)-catalyzed anti-selective arylative cyclizations of N-propargyl-N-tosyl-aminoaldehydes with acids (“anti-Wacker”-type cyclization), oxidation the resulting 5-substituted-3-hydroxy-1,2,3,6-tetrahydropyridines 3-oxo derivatives, elimina...

In addition to the w-5 olefinic acids found in other Grevillea species, about 10% ?f the acyl groups of G. decOI'a seed oil contain a hydroxy group and an w-5 double bond. Th: chamlengths of these acids are from C22 to C30 , with the largest concentration at the C26 and C28 chamle.ngths. ~le hydroxy group is located on odd carbons from carbon-5 through carbon-l3. These a~lds prevIously .were ~n...

Cortisol, 11-deoxycorticosterone, progesterone, 17 alpha-hydroxy-progesterone, 17 alpha-hydroxy-20 beta-dihydroprogesterone, or a combination of the last 2 steroids, were injected into different groups of immature female Epinephelus. None of the steroids tested had significant effects on serum electrolyte level, and hepatosomatic and gonadosomatic indices. Serum glucose concentration was elevat...

Dichloromethane root extract of Rennellia elliptica Korth. showed strong inhibition of Plasmodium falciparum growth in vitro with an IC₅₀ value of 4.04 µg/mL. A phytochemical study of the dichloromethane root extract has led to the isolation and characterization of a new anthraquinone, 1,2-dimethoxy-6-methyl-9,10-anthraquinone (1), and ten known anthraquinones: 1-hydroxy-2-methoxy-6-methyl-9,10...

Investigation of the constituents of the fruits of Morus alba LINNE (Moraceae) afforded five new nortropane alkaloids (1-5) along with nor-psi-tropine (6) and six new amino acids, morusimic acids A-F (7-12). The structures of the new compounds were determined to be 2alpha,3beta-dihydroxynortropane (1), 2beta,3beta-dihydroxynortropane (2), 2alpha,3beta,6exo-trihydroxynortropane (3), 2alpha,3beta...

Three new lignans, sambucunol A (8) ((+)-erythro-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(4-hydroxy-3-methoxycinnamoyloxypropanyl)-2-hydroxyphenoxy]-1, 3-propanediol), sambucunol B (9) ((+)-threo-1-(4-hydroxyl-3-methoxyphenyl)-2-[4-(4-hydroxy-3-methoxy-cinnamoyloxy propanyl)-2-hydroxyphenoxy]-1, 3-propanediol) and buddlenol G (10) (2-{4-[2, 3-dihydro-3-hydroxymethyl-7-hydroxy-5-(4-hydroxy-3-methoxyc...

The carcinogenicities for rats and mice of N-methyl-4-aminoazobenzene (MAB) and its hepatic microsomal metabolite N-hydroxy-N-methyl-4-aminoazobenzene (N-hydroxy-MAB) were compared under several conditions. N-Ethyl-4-aminoazobenzene, 4-aminoazobenzene, and their N-hydroxy derivatives were also included in some of the assays. About 25% of the rats given MAB or N-hydroxy-MAB (3 to 5 mmol/kg body ...

A novel binary compounds as 3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-phenyl-2H-benzo[f]indazole-4,9-dione (10) and fused 2-hydroxy-3-(4-hydroxy-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)naphthalene-1,4-dione (7) naphtho[2,3-b]furan-3,4,9(2H)-trione (6) based on lawsone ‘that plays important precursor’ was synthesized by reaction with 1,3-diphenyl-1H-pyrazole-4-carbaldehyde halo-compounds, such 2-chlor...

This study highlights the potential of ?-hydroxy amines as building blocks for aza-Michael CANs.