Genetic immunization is an attractive approach to generate antibodies because native proteins are expressed in vivo with normal posttranscriptional modifications, avoiding time-consuming and costly antigen isolation or synthesis. Hydrodynamic tail or limb vein delivery of naked plasmid DNA expression vectors was used to induce antigen-specific antibodies in mice, rats, and rabbits. Both methods...

Mitochondrial gene therapy and diagnosis have the potential to provide substantial medical benefits. However, the utility of this approach has not yet been realized because the technology available for mitochondrial gene delivery continues to be a bottleneck. We previously reported on mitochondrial gene delivery in skeletal muscle using hydrodynamic limb vein (HLV) injection. HLV injection, a u...

a lattice boltzmann method is applied to demonstrate the comparison results of simulating natural convection in an open end cavity using different hydrodynamic and thermal boundary conditions. the prandtl number in the present simulation is 0.71, rayleigh numbers are 104,105 and 106 and viscosities are selected 0.02 and 0.05. on-grid bounce-back method with first-order accuracy and non-slip met...

an attempt is made for the first time to solve the quadratic and cubic model of magneto hydrodynamic poiseuille flow of phan-thein-tanner (ptt). series solution of magneto hydrodynamic (mhd) flow is developed by using homotopy perturbation method (hpm). results are presented graphically and the effects of non-dimensional parameters on the flow field are analyzed. the results obtained reveals ma...