The curcumin is a well-known antioxidant that can scavenge free radicals efficiently. methyl radicals, generated by the metabolism of various genotoxic compounds such as hydrazines and peroxides, methylate sites in DNA. Herein, we have carried out density functional theory calculations to investigate scavenging activity toward ethyl through radical adduct formation (RAF), hydrogen atom transfer...

treatment of tuberculosis was an obstacle for ages. in spite of good drugs, the disease is not under control. thus, the need for more drugs existed. searching for a new drug demands much investment on the time, money and human resources. there are many drugs with antitubercular action that are discovered and explored in the last century. the most common drug, isoniazid, is now a frontrunner ant...

Acetylhydrazine, a metabolite of isoniazid, a widely used antituberculosis drug, and isopropylhydrazine, a metabolite of iproniazid, an antidepressant removed from clinical use because of high incidence of liver injury, were oxidized by cytochrome P-450 enzymes in human and rat liver microsomes to highly reactive acylating and alkylating agents. Covalent binding of these metabolites to liver ma...

In the title compound, C(2)H(6)N(2)O, a hydrazine derivative, the asymmetric unit contains two mol-ecules with similar geom-etries. The crystal structure is stabilized by inter-molecular N-H⋯O hydrogen bonds.

Many hydrazine derivatives show remarkable biological activities [1]. Hydrazine derivatives are well known among pesticides, drugs, amino acid precursors, and synthetic building blocks for heterocycle synthesis. Several similar compounds were shown to be effective for treatment of tuberculosis, Parkinson’s disease, and hypertension [2]. Also, hydrazine-based peptidomimetics (azapeptides) are fo...

Reaction of the title compound with hydrazine in the presence of air gives the 1-unsubstituted parent system via oxidative dehydrazination of the 1-hydrazino intermediate. The latter can be obtained in high yield by carrying out the hydrazinolysis step under inert gas, and it is smoothly converted into [1,2,4]-triazolo[4',3':1,6]pyridazino[4,5- b]indoles.

The asymmetric unit of the title compound, C(7)H(6)ClN(3)S, consists of two crystallographically independent mol-ecules (A and B). The dihedral angle between the benzothia-zole ring system and the hydrazine group is 8.71 (6)° in mol-ecule A and 7.16 (6)° in mol-ecule B. The N-N-C-N and N-N-C-S torsion angles involving the hydrazine group are 170.89 (9) and -9.96 (13)°, respectively, in mol-ecul...