نتایج جستجو برای: hydatidiform moles

تعداد نتایج: 2754  

Journal: :iranian journal of basic medical sciences 0
fatemeh atabaki pasdar department of anatomy and cell biology, mashhad university of medical science, mashhad, iran alireza khooei department of pathology, imam reza hospital, mashhad university of medical sciences, mashhad, iran alireza fazel department of anatomy and cell biology, mashhad university of medical sciences, mashhad, iran mahmoud mahmoudi immunology research centre, buali research institue, mashhad university of medical sciences, mashhad, iran mohammad reza nikravesh department of anatomy and cell biology, mashhad university of medical sciences, mashhad, iran mohammad khaje delui department of medical ethics, mashhad university of medical sciences, mashhad, iran

objective(s)distinction of hydatidiform moles from non-molar specimens and subclassification of hydatidiform moles as complete and partial are important for clinical practice, but diagnosis based solely on histomorphology suffers from poor interobserver reproducibility. nowadays, pathologists rely on molecular techniques, however these methods are technically difficult, relatively expensive, an...

Journal: :journal of research in medical sciences 0
minoo erfaniana resident of anatomoclinical pathology, mashhad medical university, mashhad, iran. nourieh sharifi associate professor of anatomoclinical pathology, mashhad medical university, mashhad, iran abas ali omidic professor of anatomoclinical pathology, mashhad medical university, mashhad, iran.

normal 0 false false false microsoftinternetexplorer4 background : despite well-described histopathologic criteria, the distinction of spontaneous abortion from hydatidiform mole and complete hydatidiform mole from partial hydatidiform mole remains a problem because of interobserver and intraobserver variability. the aim of this study was to evaluate the value of two immunohistochemical markers...

2006
Nono Wake Toshio Seki Hiromasa Fujita Hitoshi Okubo Keiichiro Sakai Kazuhiko Okuyama Hiroshi Hayashi Yoshihiro Shiina Hitoshi Sato Makoto Kuroda

There are two main mechanisms of origin for complete hydatidiform mole: (a) fertilization of an empty egg by a haploid sperm followed by duplication (monospermic mole); and (b) fertilization of such an egg by two haploid spermatozoa (dispermie mole). The former is inevitably homozygous (homozygous mole), whereas the latter may be heterozygous for a given genetic marker (heterozygous mole). A re...

Journal: :Journal of clinical pathology 1987
J D Hemming P Quirke C Womack M Wells C W Elston C C Bird

Histopathological assessment and flow cytometric analyses were carried out on 32 placentas (representative of each trimester) and 88 molar pregnancies. Three first trimester placentas were triploid, and the remaining 29 placentas were diploid. Of the 88 cases originally diagnosed as molar pregnancies, 26 were triploid (two complete moles, 20 partial moles, and four hydropic abortions); 59 were ...

2016
Neil J Sebire Philippa C May Baljeet Kaur Michael J Seckl Rosemary A Fisher

BACKGROUND Pregnancies affected by non-molar chromosomal abnormality may sometimes demonstrate abnormal chorionic villous morphology that is similar to partial hydatidiform mole. Determination of the underlying aetiology may be difficult in such cases. CASE PRESENTATION This report describes a case referred to the regional trophoblastic disease unit as a possible hydatidiform mole that demons...

Journal: :Genome research 2005
Yoji Kukita Katsuyuki Miyatake Renee Stokowski David Hinds Koichiro Higasa Norio Wake Toshio Hirakawa Hidenori Kato Takao Matsuda Krishna Pant David Cox Tomoko Tahira Kenshi Hayashi

We present genome-wide definitive haplotypes, determined using a collection of 74 Japanese complete hydatidiform moles, each carrying a genome derived from a single sperm. The haplotypes incorporate 281,439 common SNPs, genotyped with a high throughput array-based oligonucleotide hybridization technique. Comparison of haplotypes inferred from pseudoindividuals (constructed from randomized mole ...

2009
Minoo Erfanian Nourieh Sharifi Abas Ali Omidi

BACKGROUND Despite well-described histopathologic criteria, the distinction of spontaneous abortion from hydatidiform mole and complete hydatidiform mole from partial hydatidiform mole remains a problem because of interobserver and intraobserver variability. The aim of this study was to evaluate the value of two immunohistochemical markers in the differential diagnosis of subgroups of lesions o...

Journal: :American journal of clinical pathology 2008
Robin D LeGallo Edward B Stelow Nilsa C Ramirez Kristen A Atkins

Fluorescent in situ hybridization (FISH) for HER2 performed on paraffin-embedded tissue samples and immunohistochemical analysis for p57 may be useful ancillary studies to aid in the diagnosis and classification of hydatidiform moles (HMs). HER2 FISH was validated against 24 paraffin-embedded sections of HMs and hydropic abortions and showed an 85% concordance rate. A morphologic assessment bas...

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