The purpose of this study was to evaluate human umbilical cord blood as an alternative to bone marrow in the provision of transplantable stem/progenitor cells for hematopoietic reconstitution. Although no direct quantitative assay for human hematopoietic repopulating cells is at present available, the granulocyte-macrophage progenitor cell (CFU-GM) assay has been used with success as a valid in...

stem cell therapy is a powerful technique for the treatment of a number of diseases. stem cells are derived from different tissue sources, the most important of which are the bone marrow (bm), umbilical cord (uc) blood and liver. human uc mesenchymal stem cells (huc-mscs) are multipotent, non-hematopoietic stem cells that have the ability to self-renew and differentiate into other cells and tis...

Background: Fetal asphyxia and the consequent neurological damages could be avoided if the risk factors are controlled at earlier stages. Umbilical cord arterial blood gas (UCABG) seems to be related to the Apgar scores, as well as the neonatal morbidity and mortality rates. Therefore, we designed this study to assess the correlation between the Apgar score and UCABG i...

BACKGROUND AND PURPOSE Severe intraventricular hemorrhage (IVH) in premature infants and the ensuing posthemorrhagic hydrocephalus cause significant mortality and neurological disabilities, and there are currently no effective therapies. This study determined whether intraventricular transplantation of human umbilical cord blood-derived mesenchymal stem cells prevents posthemorrhagic hydrocepha...

successful cure of the hematological manifestations of Fanconi’s anemia (4), thousands of people worldwide have been beneficiaries of these therapeutic advantages, and to date, nearly 500 umbilical cord blood hematopoietic stem cell transplants occur annually in the United States (5). The vast majority of these hematopoietic transplants occur using publicly banked umbilical cord blood, some uti...

OBJECTIVE To evaluate the risks and benefits of umbilical cord blood banking for future stem cell transplantation and to provide guidelines for Canadian perinatal care providers regarding the counselling, procedural, and ethical implications of this potential therapeutic option. OPTIONS Selective or routine collection and storage of umbilical cord blood for future autologous (self) or allogen...

Umbilical cord blood has served as an alternative to bone marrow for hematopoietic transplantation since the late 1980s. Numerous clinical studies have proven the efficacy of umbilical cord blood. Moreover, the possible immaturity of cells in umbilical cord blood gives more options to recipients with HLA mismatch and allows for the use of umbilical cord blood from unrelated donors. However, mor...

OBJECTIVE In this study, we aim to demonstrate that measurement of the malondialdehyde (MDA) level in the umbilical cord blood of newborn infants born via cesarean section (C/S) and normal vaginal delivery (NVD) is indicative of oxidative stress during the perinatal period. METHODS The study was conducted at Bakirkoy Training and Research Hospital between January 2006 and April 2006 on 15 new...