Human herpesvirus-6 (HHV-6), a mature T-cell lymphotropic virus, is a newly recognized member of the herpes virus family and shares limited homology with human cytomegalovirus. HHV-6 has been identified as the etiologic agent of the childhood illness exanthem subitum (roseola infantum). Widespread acquisition of this virus has been demonstrated to occur early in childhood, with fever as the mos...

Herpes B-virus,cercopithecine herpesvirus 1;herpesvirus simian endemic in Asian macaques is related to herpes simplex(HSV) type 1 in humans; infection with herpes B-virus in humans can result in fatal encephalitis and neurologic impairment. Human infections have been by bites, scratches, and percutaneous inoculation. HerpesB-virus infection causes minimal morbidity in macaques. Inhumans herpes ...

background and aims: several drugs are being used in treatment of hsv infection in human but still introducing an effective safe drug is desirable. methods: we investigated the inhibitory effect of morphine on replication of hsv in vitro. results: the results indicated that a concentration of up to 200 ug/ml morphine had a limited effect on vero cell viability. at this concentration the growth ...

Herpes virus infections are frequent in renal transplant recipients. Some herpes viruses are not only responsible for life-threatening infections and renal graft injury but can also increase the risk of malignancy. Three herpes viruses, namely cytomegalovirus (CMV) or human herpes virus 5, Epstein-Barr virus (EBV) or herpes virus 4 and human herpes virus 8 (HHV8), may play an oncogenic role. Th...

An encephalitic illness with a fatal outcome occurred in a 9 month old girl with virologically confirmed exanthem subitum. Human herpes-virus-6 (HHV-6) DNA was found in the cerebrospinal fluid at the acute stage of the disease by the polymerase chain reaction, but the virus antigen was not detected in her brain tissue. This suggests that HHV-6-induced encephalitis/encephalopathy may be due to a...

Herpes simplex virus is most probably maintained in the ganglion neurons of the peripheral nervous system of humans in a latent form that can reactivate to produce recurrent disease. As an approximation of this cell-virus interaction, we have constructed a herpes simplex virus latency in vitro model system using human fetus sensory neurons as the host cell. Human fetus neurons were characterize...

Herpes zoster (Shingles; Zona) is an acute infectious skin disease that is caused by the reactivation of varicella zoster virus (VZV). After the initial infection (chickenpox) or vaccination, the virus remains inactive or latent in the dorsal root ganglia (DRG); when decreasing cell mediated immunity (CMI) occurs, the virus is reactivated from a latent phase to a lytic phase and frequently repl...